OSGIN1
Oxidative stress-induced growth inhibitor 1
Protein Summary
Regulates the differentiation and proliferation of normal cells through the regulation of cell death. This gene encodes an oxidative stress response protein that regulates cell death. Expression of the gene is regulated by p53 and is induced by DNA damage. The protein regulates apoptosis by inducing cytochrome c release from mitochondria. It also appears to be a key regulator of both inflammatory and anti-inflammatory molecules. The loss of this protein correlates with uncontrolled cell growth and tumor formation. Naturally occurring read-through transcription exists between this gene and the neighboring upstream malonyl-CoA decarboxylase (MLYCD) gene, but the read-through transcripts are unlikely to produce a protein product. [provided by RefSeq, Aug 2011]
- ENST00000343939
- ENSP00000343376
- ENSG00000140961
- ENST00000361711
- ENSP00000355374
- ENST00000393306
- ENSP00000376983
- OKL38
- BDGI
- OKL38
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.89 | ||
virus perturbation | 0.85 | ||
cell type or tissue | 0.77 | ||
transcription factor binding site profile | 0.72 | ||
transcription factor | 0.64 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 32.62 (req: < 5)
Gene RIFs: 12 (req: <= 3)
Antibodies: 125 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 32.62 (req: >= 5)
Gene RIFs: 12 (req: > 3)
Antibodies: 125 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0