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Tchem
LEF1
Lymphoid enhancer-binding factor 1

Protein Summary
Description
Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling. Isoform 5 transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. Isoform 1 transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells. This gene encodes a transcription factor belonging to a family of pr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265165
  • ENSP00000265165
  • ENSG00000138795
  • ENST00000379951
  • ENSP00000369284
  • ENST00000438313
  • ENSP00000406176
  • ENST00000506680
  • ENSP00000422334
  • ENST00000510624
  • ENSP00000422840

Symbol
  • LEF-1
  • TCF10
  • TCF7L3
  • TCF1ALPHA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
PubMedID
0.98
hub protein
0.85
transcription factor
0.83


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 608.83   (req: < 5)
Gene RIFs: 204   (req: <= 3)
Antibodies: 722   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 608.83   (req: >= 5)
Gene RIFs: 204   (req: > 3)
Antibodies: 722   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 89
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0