Tbio GNPTG N-acetylglucosamine-1-phosphotransferase subunit gamma

Protein Summary

Description

Non-catalytic subunit of the N-acetylglucosamine-1-phosphotransferase complex, an enzyme that catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. Binds and presents the high mannose glycans of the acceptor to the catalytic alpha and beta subunits (GNPTAB). Enhances the rate of N-acetylglucosamine-1-phosphate transfer to the oligosaccharides of acid hydrolase acceptors. This gene encodes the gamma sunbunit of the N-acetylglucosamine-1-phosphotransferase complex. This hexameric complex, composed of alpha, beta and gamma subunits, catalyzes the first step in synthesis of a mannose 6-phosphate lysosomal recognition marker. This enzyme complex is necessary for targeting of lysosomal hydrolases to the lysosome. Mutations in the gene encoding the gamma subunit have been associated with mucolipidosis IIIC, also known as mucolipidosis III gamma.[provided by RefSeq, Feb 2010]

Uniprot Accession IDs

• Q9UJJ9
• B2R556
• Q6XYD7
• Q96L13

Gene Name

• GNPTG

Ensembl ID

• ENST00000204679
• ENSP00000204679
• ENSG00000090581

Symbol

• C16orf27
• GNPTAG
• RJD9
• GNPTAG
• LP2537
• C16orf27

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.79
kinase perturbation	0.71
tissue	0.63
cellular component	0.58
cell type or tissue	0.56

Protein Classes

PANTHER Classes

Protein / Transferase / N-acetylglucosamine-1-phosphotransferase Subunit Gamma

Protein / Enzyme Modulator / N-acetylglucosamine-1-phosphotransferase Subunit Gamma

DTO Classes

Protein / Enzyme / Transferase / N-acetylglucosamine-1-phosphotransferase Subunit Gamma

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.08   (req: < 5)

Gene RIFs: 24   (req: <= 3)

Antibodies: 97   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.08   (req: >= 5)

Gene RIFs: 24   (req: > 3)

Antibodies: 97   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0