Tbio STAG3 Cohesin subunit SA-3

Protein Summary

Description

Meiosis specific component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I. The protein encoded by this gene is expressed in the nucleus and is a subunit of the cohesin complex which regulates the cohesion of sister chromatids during cell division. A mutation in this gene is associated with premature ovarian failure. Alternate splicing results in multiple transcript variants encoding distinct isoforms. This gene has multiple pseudogenes. [provided by RefSeq, Apr 2014]

Uniprot Accession IDs

• Q9UJ98
• A6H8Z1
• B4DZ10
• D6W5U8
• H7BYK9
• Q8NDP3

Gene Name

• STAG3

Ensembl ID

• ENST00000317296
• ENSP00000319318
• ENSG00000066923
• ENST00000394018
• ENSP00000377586
• ENST00000426455
• ENSP00000400359
• ENST00000620100
• ENSP00000484098

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.78
gene perturbation	0.76
virus perturbation	0.72
PubMedID	0.67
cell line	0.62

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Cohesin Subunit Sa-3

DTO Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Cohesin Subunit Sa-3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.12   (req: < 5)

Gene RIFs: 22   (req: <= 3)

Antibodies: 145   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.12   (req: >= 5)

Gene RIFs: 22   (req: > 3)

Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0