Property Summary

NCBI Gene PubMed Count 36
PubMed Score 137.07
PubTator Score 198.96

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (2)

Disease Target Count P-value
osteosarcoma 7933 7.78699792289536E-5
Multiple myeloma 1328 3.60308032233812E-4
dermatomyositis 967 4.80431040485265E-4
glioblastoma 5572 6.55990966697567E-4
psoriasis 6685 7.49647384105812E-4
astrocytoma 1493 0.00149811733296646
adult high grade glioma 2148 0.00378764506486732
Pick disease 1893 0.00679365225408813
ovarian cancer 8492 0.00956073697503234
chronic rhinosinusitis 512 0.0398800914515312
subependymal giant cell astrocytoma 2287 0.0467237872850013

Expression

  Differential Expression (11)

Disease log2 FC p
Multiple myeloma 1.269 0.000
psoriasis 1.200 0.001
osteosarcoma -2.214 0.000
astrocytoma -1.300 0.001
glioblastoma -1.100 0.001
adult high grade glioma -1.100 0.004
subependymal giant cell astrocytoma -1.146 0.047
Pick disease -1.100 0.007
ovarian cancer 1.100 0.010
chronic rhinosinusitis -1.115 0.040
dermatomyositis 1.600 0.000

Synonym

Accession Q9UII2 Q5JXL8 Q6IAQ7 Q9BSL9
Symbols IP
ATPI
ATPIP

Gene

PANTHER Protein Class (1)

  Ortholog (8)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG Inparanoid

Gene RIF (21)

PMID Text
26876430 Upon IF1 interaction with the ATP synthase both the synthetic and hydrolytic activities of the engine of oxidative phosphorylation are inhibited. (Review)
26595676 Data indicate that oxidative phosphorylation (OXPHOS) is inhibited in the liver of mice expressing human ATPase inhibitory factor 1 (hIF1).
26387949 PKA phosphorylates the ATPase inhibitory factor 1 and inactivates its capacity to bind and inhibit the mitochondrial H(+)-ATP synthase.
26381881 IF1 was overexpressed in bladder cancer; concluded that IF1 may be a novel therapeutic target for bladder cancer
25776485 These results indicate that IF1 may serve as a prognostic marker and promotes tumor growth and metastasis in gastric cancer.
25605724 interaction of IF1 with the complex either directly, by increasing the catalytic activity of the enzyme, or indirectly, by improving the structure of mitochondrial cristae, can increase the oxidative phosphorylation rate in osteosarcoma cells
25042864 promotes hepatocellular carcinoma angiogenesis and metastasis by up-regulation of Snai1 and VEGF transcription
24685140 Inhibition of ATPIF1 ameliorates complex III blockade in primary hepatocytes, a cell type afflicted in severe mitochondrial disease.
24521670 The expression of human ATPase inhibitory factor 1 (hIF1) inhibits the activity of oxidative phosphorylation and mediates the shift of neurons to an enhanced aerobic glycolysis.
24005319 ATPase inhibitory factor 1 (ATPIF1/IF1) was identified as essential for PARK2 recruitment and mitophagy in cultured cells.
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AA Sequence

MAVTALAARTWLGVWGVRTMQARGFGSDQSENVDRGAGSIREAGGAFGKREQAEEERYFRAQSREQLAAL      1 - 70
KKHHEEEIVHHKKEIERLQKEIERHKQKIKMLKHDD                                       71 - 106
//

Text Mined References (43)

PMID Year Title
26876430 2016 The ATPase Inhibitory Factor 1 (IF1): A master regulator of energy metabolism and of cell survival.
26595676 2016 Down-regulation of oxidative phosphorylation in the liver by expression of the ATPase inhibitory factor 1 induces a tumor-promoter metabolic state.
26387949 2015 PKA Phosphorylates the ATPase Inhibitory Factor 1 and Inactivates Its Capacity to Bind and Inhibit the Mitochondrial H(+)-ATP Synthase.
26381881 2015 Silencing of ATPase Inhibitory Factor 1 Inhibits Cell Growth via Cell Cycle Arrest in Bladder Cancer.
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25776485 2015 ATPase inhibitory factor 1 is a prognostic marker and contributes to proliferation and invasion of human gastric cancer cells.
25605724 2015 The inhibitor protein (IF1) of the F1F0-ATPase modulates human osteosarcoma cell bioenergetics.
25042864 2014 Reciprocal activation between ATPase inhibitory factor 1 and NF-?B drives hepatocellular carcinoma angiogenesis and metastasis.
24685140 2014 Inhibition of ATPIF1 ameliorates severe mitochondrial respiratory chain dysfunction in mammalian cells.
24521670 2014 In vivo inhibition of the mitochondrial H+-ATP synthase in neurons promotes metabolic preconditioning.
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