Property Summary

NCBI Gene PubMed Count 15
PubMed Score 14.66
PubTator Score 11.07

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (2)

Disease Target Count
Embryo Loss 9
Disease Target Count P-value
glioblastoma 5572 3.73685028370348E-5
adult high grade glioma 2148 7.76201023773772E-5
osteosarcoma 7933 2.43289686515072E-4
Multiple myeloma 1328 4.38961359020448E-4
ovarian cancer 8492 4.44355873011378E-4
Waldenstrons macroglobulinemia 765 0.00263957904019437
dermatomyositis 967 0.00346709672661185
astrocytic glioma 2241 0.0272190023144543

Expression

  Differential Expression (8)

Disease log2 FC p
Waldenstrons macroglobulinemia 1.001 0.003
Multiple myeloma 1.254 0.000
astrocytic glioma -1.200 0.027
osteosarcoma -1.095 0.000
glioblastoma -1.200 0.000
adult high grade glioma -1.100 0.000
ovarian cancer 1.200 0.000
dermatomyositis 1.100 0.003

Synonym

Accession Q9UIC8 A6NL89 A8K770 Q53FC5 Q96CI5 Q9H6I9 Q9NTG4 Q9Y378
Symbols LCMT
PPMT1
CGI-68

Gene

PANTHER Protein Class (2)

PDB

3IEI   3O7W   3P71  

  Ortholog (13)

Species Source
Chimp OMA EggNOG
Macaque OMA Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Platypus OMA EggNOG Inparanoid
Chicken OMA EggNOG Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG Inparanoid
C. elegans OMA EggNOG Inparanoid
S.cerevisiae OMA EggNOG Inparanoid

Gene RIF (7)

PMID Text
25839665 LCMT1-PME-1 methylation equilibrium is critical for regulating mitotic spindle size and thereby proper cell division
23943618 alterations in the membrane localization of PP2A and Tau following down-regulation of LCMT1 may lead to PP2A and Tau dysfunction in AD.
22732552 GSK-3beta can inhibit PP2A by increasing the inhibitory L309-demethylation involving upregulation of PME-1 and inhibition of PPMT1
22443683 Data indicate that PP2A holoenzyme biogenesis and activity are controlled by five PP2A modulators, consisting of alpha4, PTPA, LCMT1, PME-1 and TIPRL1, which serve to prevent promiscuous phosphatase activity until the holoenzyme is completely assembled.
21292165 determined crystal structures of human LCMT-1 in isolation and in complex with PP2A stabilized by a cofactor mimic. The structures show that the LCMT-1 active-site pocket recognizes the carboxyl terminus of PP2A
21206058 X-ray crystal structure of human LCMT1 protein in complex with the cofactor S-adenosylmethionine (AdoMet) has been solved to a resolution of 2 A.
17724024 LCMT-1 is important for normal progression through mitosis and cell survival and is essential for embryonic development

AA Sequence

MATRQRESSITSCCSTSSCDADDEGVRGTCEDASLCKRFAVSIGYWHDPYIQHFVRLSKERKAPEINRGY      1 - 70
FARVHGVSQLIKAFLRKTECHCQIVNLGAGMDTTFWRLKDEDLLPSKYFEVDFPMIVTRKLHSIKCKPPL     71 - 140
SSPILELHSEDTLQMDGHILDSKRYAVIGADLRDLSELEEKLKKCNMNTQLPTLLIAECVLVYMTPEQSA    141 - 210
NLLKWAANSFERAMFINYEQVNMGDRFGQIMIENLRRRQCDLAGVETCKSLESQKERLLSNGWETASAVD    211 - 280
MMELYNRLPRAEVSRIESLEFLDEMELLEQLMRHYCLCWATKGGNELGLKEITY                    281 - 334
//

Text Mined References (18)

PMID Year Title
25839665 2015 A LCMT1-PME-1 methylation equilibrium controls mitotic spindle size.
23943618 2013 Leucine carboxyl methyltransferase 1 (LCMT1)-dependent methylation regulates the association of protein phosphatase 2A and Tau protein with plasma membrane microdomains in neuroblastoma cells.
22732552 2012 Glycogen synthase kinase-3? regulates leucine-309 demethylation of protein phosphatase-2A via PPMT1 and PME-1.
22443683 2013 The biogenesis of active protein phosphatase 2A holoenzymes: a tightly regulated process creating phosphatase specificity.
21292165 2011 The structural basis for tight control of PP2A methylation and function by LCMT-1.
21269460 2011 Initial characterization of the human central proteome.
21206058 2011 The structure of human leucine carboxyl methyltransferase 1 that regulates protein phosphatase PP2A.
17974005 2007 The full-ORF clone resource of the German cDNA Consortium.
17724024 2007 Leucine carboxyl methyltransferase-1 is necessary for normal progression through mitosis in mammalian cells.
17207965 2007 hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes.
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