Property Summary

NCBI Gene PubMed Count 15
Grant Count 28
R01 Count 24
Funding $1,097,346.94
PubMed Score 14.66
PubTator Score 11.07

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (8)

Disease log2 FC p
Waldenstrons macroglobulinemia 1.001 0.003
Multiple myeloma 1.254 0.000
astrocytic glioma -1.200 0.027
osteosarcoma -1.095 0.000
glioblastoma -1.200 0.000
adult high grade glioma -1.100 0.000
ovarian cancer 1.200 0.000
dermatomyositis 1.100 0.003

Gene RIF (7)

PMID Text
25839665 LCMT1-PME-1 methylation equilibrium is critical for regulating mitotic spindle size and thereby proper cell division
23943618 alterations in the membrane localization of PP2A and Tau following down-regulation of LCMT1 may lead to PP2A and Tau dysfunction in AD.
22732552 GSK-3beta can inhibit PP2A by increasing the inhibitory L309-demethylation involving upregulation of PME-1 and inhibition of PPMT1
22443683 Data indicate that PP2A holoenzyme biogenesis and activity are controlled by five PP2A modulators, consisting of alpha4, PTPA, LCMT1, PME-1 and TIPRL1, which serve to prevent promiscuous phosphatase activity until the holoenzyme is completely assembled.
21292165 determined crystal structures of human LCMT-1 in isolation and in complex with PP2A stabilized by a cofactor mimic. The structures show that the LCMT-1 active-site pocket recognizes the carboxyl terminus of PP2A
21206058 X-ray crystal structure of human LCMT1 protein in complex with the cofactor S-adenosylmethionine (AdoMet) has been solved to a resolution of 2 A.
17724024 LCMT-1 is important for normal progression through mitosis and cell survival and is essential for embryonic development

AA Sequence

MATRQRESSITSCCSTSSCDADDEGVRGTCEDASLCKRFAVSIGYWHDPYIQHFVRLSKERKAPEINRGY      1 - 70
FARVHGVSQLIKAFLRKTECHCQIVNLGAGMDTTFWRLKDEDLLPSKYFEVDFPMIVTRKLHSIKCKPPL     71 - 140
SSPILELHSEDTLQMDGHILDSKRYAVIGADLRDLSELEEKLKKCNMNTQLPTLLIAECVLVYMTPEQSA    141 - 210
NLLKWAANSFERAMFINYEQVNMGDRFGQIMIENLRRRQCDLAGVETCKSLESQKERLLSNGWETASAVD    211 - 280
MMELYNRLPRAEVSRIESLEFLDEMELLEQLMRHYCLCWATKGGNELGLKEITY                    281 - 334
//

Text Mined References (18)

PMID Year Title
25839665 2015 A LCMT1-PME-1 methylation equilibrium controls mitotic spindle size.
23943618 2013 Leucine carboxyl methyltransferase 1 (LCMT1)-dependent methylation regulates the association of protein phosphatase 2A and Tau protein with plasma membrane microdomains in neuroblastoma cells.
22732552 2012 Glycogen synthase kinase-3? regulates leucine-309 demethylation of protein phosphatase-2A via PPMT1 and PME-1.
22443683 2013 The biogenesis of active protein phosphatase 2A holoenzymes: a tightly regulated process creating phosphatase specificity.
21292165 2011 The structural basis for tight control of PP2A methylation and function by LCMT-1.
21269460 2011 Initial characterization of the human central proteome.
21206058 2011 The structure of human leucine carboxyl methyltransferase 1 that regulates protein phosphatase PP2A.
17974005 2007 The full-ORF clone resource of the German cDNA Consortium.
17724024 2007 Leucine carboxyl methyltransferase-1 is necessary for normal progression through mitosis in mammalian cells.
17207965 2007 hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes.
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