Tbio SLC24A2 Sodium/potassium/calcium exchanger 2

Protein Summary

Description

Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). This gene encodes a member of the calcium/cation antiporter superfamily of transport proteins. The encoded protein belongs to the SLC24 branch of exchangers, which can mediate the extrusion of one Ca2+ ion and one K+ ion in exchange for four Na+ ions. This family member is a retinal cone/brain exchanger that can mediate a light-induced decrease in free Ca2+ concentration. This protein may also play a neuroprotective role during ischemic brain injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

Uniprot Accession IDs

• Q9UI40
• B7ZLL8
• Q9NTN5
• Q9NZQ4

Gene Name

• SLC24A2

Ensembl ID

• ENST00000286344
• ENSP00000286344
• ENSG00000155886
• ENST00000341998
• ENSP00000344801

Symbol

• NCKX2
• NCKX2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
microRNA	0.91
trait	0.86
cell line	0.59
biological process	0.57

Protein Classes

PANTHER Classes

Protein / Transporter / Sodium/potassium/calcium Exchanger 2

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc24 Family Of Sodium/potassium/calcium Exchangers / Sodium/potassium/calcium Exchanger 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.74   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 42   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.74   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 42   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0