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Tbio
PUF60
Poly(U)-binding-splicing factor PUF60

Protein Summary
Description
DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation. In association with FUBP1 regulates MYC transcription at the P2 promoter through the core-TFIIH basal transcription factor. Acts as a transcriptional repressor through the core-TFIIH basal transcription factor. Represses FUBP1-induced transcriptional activation but not basal transcription. Decreases ERCC3 helicase activity. Does not repress TFIIH-mediated transcription in xeroderma pigmentosum complementation group B (XPB) cells. Is also involved in pre-mRNA splicing. Promotes splicing of an intron with weak 3'-splice site and pyrimidine tract in a cooperative manner with U2AF2. Involved in apoptosis induction when overexpressed in HeLa cells. Isoform 6 failed to repress MYC transcription and inhibited FIR-induced apoptosis in colorectal cancer. Isoform 6 may contribute to tumor progression by enabling increased MYC expression and greater resistance to ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313352
  • ENSP00000322016
  • ENSG00000179950
  • ENST00000349157
  • ENSP00000322036
  • ENST00000453551
  • ENSP00000402953
  • ENST00000456095
  • ENSP00000395417
  • ENST00000526683
  • ENSP00000434359
  • ENST00000527197
  • ENSP00000431960
  • ENST00000612237
  • ENSP00000478495
  • ENSG00000274081
  • ENST00000620341
  • ENSP00000484860
  • ENST00000620953
  • ENSP00000478209
  • ENST00000632444
  • ENSP00000487945
  • ENST00000633206
  • ENSP00000487930

Symbol
  • FIR
  • ROBPI
  • SIAHBP1
  • FIR
  • VRJS
  • RoBPI
  • SIAHBP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
kinase perturbation
1
co-expressed gene
0.99
transcription factor binding site profile
0.87


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.94   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 413   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.94   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 413   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0