Tchem ASIC3 Acid-sensing ion channel 3

Protein Summary

Description

Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties. This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 2 has been observed as proton-gated channels sensitive to gadolinium. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012]

Uniprot Accession IDs

• Q9UHC3
• B2R9V0
• O60263
• O75906
• Q59FN9
• Q9UER8
• Q9UHC4
• ASIC3

Gene Name

• ASIC3

Ensembl ID

• ENST00000297512
• ENSP00000297512
• ENSG00000213199
• ENST00000349064
• ENSP00000344838
• ENST00000357922
• ENSP00000350600
• ENST00000377904
• ENSP00000367136
• ENST00000468325
• ENSP00000418605

Symbol

• ACCN3
• SLNAC1
• TNAC1
• ACCN3
• TNaC1
• DRASIC
• SLNAC1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.88
cell type or tissue	0.65
tissue sample	0.61
cellular component	0.6
disease perturbation	0.56

Protein Classes

PANTHER Classes

Protein / Transporter / Ion Channel / Acid-sensing Ion Channel 3

DTO Classes

Protein / Ion Channel / Amiloride-sensitive Sodium Channel Family / Acid-sensing Ion Channel 3 (Asic3) Subfamily / Acid-sensing Ion Channel 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 339.64   (req: < 5)

Gene RIFs: 32   (req: <= 3)

Antibodies: 160   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 339.64   (req: >= 5)

Gene RIFs: 32   (req: > 3)

Antibodies: 160   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 36

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5