Tbio SWAP70 Switch-associated protein 70

Protein Summary

Description

Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity).

Uniprot Accession IDs

• Q9UH65
• D3DQV1
• O75135
• Q7LCY6
• Q9P061
• Q9P0Z8
• SWAP-70

Gene Name

• SWAP70

Ensembl ID

• ENST00000318950
• ENSP00000315630
• ENSG00000133789

Symbol

• KIAA0640
• HSPC321
• SWAP-70

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.89
kinase perturbation	0.88
molecular function	0.88
virus perturbation	0.85
transcription factor perturbation	0.84

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Switch-associated Protein 70

DTO Classes

Protein / Nucleic Acid Binding / Switch-associated Protein 70

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.21   (req: < 5)

Gene RIFs: 18   (req: <= 3)

Antibodies: 374   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.21   (req: >= 5)

Gene RIFs: 18   (req: > 3)

Antibodies: 374   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0