Tbio LIMD1 LIM domain-containing protein 1

Protein Summary

Description

Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation.

Uniprot Accession IDs

• Q9UGP4
• Q17RQ1
• Q9BQQ9
• Q9NQ47

Gene Name

• LIMD1

Ensembl ID

• ENST00000273317
• ENSP00000273317
• ENSG00000144791

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.94
biological process	0.9
disease perturbation	0.9
virus perturbation	0.88
transcription factor binding site profile	0.75

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Cofactor / Lim Domain-containing Protein 1

DTO Classes

Protein / Transcription Factor / Transcription Cofactor / Lim Domain-containing Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.24   (req: < 5)

Gene RIFs: 24   (req: <= 3)

Antibodies: 197   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.24   (req: >= 5)

Gene RIFs: 24   (req: > 3)

Antibodies: 197   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0