Tchem PRKAG2 5'-AMP-activated protein kinase subunit gamma-2

Protein Summary

Description

AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive. AMP-activated protein kinase (AMPK) is a heterotrimeric protein composed of a catalytic alpha subunit, a noncatalytic beta subunit, and a noncatalytic regulatory gamma subunit. Various forms of each of these subunits exist, encoded by different genes. AMPK is an important energy-sensing enzyme that monitors cellular energy status and functions by inactivating key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This gene is a member of the AMPK gamma subunit family. Mutations in this gene have been associated with Wolff-Parkinson-White syndrome, familial hypertrophic cardiomyopathy, and glycogen storage disease of the heart. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jan 2015]

Uniprot Accession IDs

• Q9UGJ0
• Q53Y07
• Q6NUI0
• Q75MP4
• Q9NUZ9
• Q9UDN8
• Q9ULX8
• AMPK gamma2

Gene Name

• PRKAG2

Ensembl ID

• ENST00000287878
• ENSP00000287878
• ENSG00000106617
• ENST00000392801
• ENSP00000376549
• ENST00000418337
• ENSP00000387386

Symbol

• AAKG
• CMH6
• WPWS
• AAKG2
• H91620p

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
drug perturbation	1
molecular function	1
trait	0.99
transcription factor perturbation	0.97

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Kinase Modulator / 5'-amp-activated Protein Kinase Subunit Gamma-2

DTO Classes

Protein / Enzyme Modulator / Kinase Modulator / 5'-amp-activated Protein Kinase Subunit Gamma-2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 166.21   (req: < 5)

Gene RIFs: 70   (req: <= 3)

Antibodies: 151   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 166.21   (req: >= 5)

Gene RIFs: 70   (req: > 3)

Antibodies: 151   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 13

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0