Tbio TES Testin

Protein Summary

Description

Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor. Inhibits tumor cell growth. Cancer-associated chromosomal changes often involve regions containing fragile sites. This gene maps to a commom fragile site on chromosome 7q31.2 designated FRA7G. This gene is similar to mouse Testin, a testosterone-responsive gene encoding a Sertoli cell secretory protein containing three LIM domains. LIM domains are double zinc-finger motifs that mediate protein-protein interactions between transcription factors, cytoskeletal proteins and signaling proteins. This protein is a negative regulator of cell growth and may act as a tumor suppressor. This scaffold protein may also play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Multiple protein isoforms are encoded by transcript variants of this gene.[provided by RefSeq, Mar 2011]

Uniprot Accession IDs

• Q9UGI8
• A4D0U6
• Q9GZQ1
• Q9HAJ9

Gene Name

• TES

Ensembl ID

• ENST00000358204
• ENSP00000350937
• ENSG00000135269
• ENST00000393481
• ENSP00000377121

Symbol

• TESS
• TESS-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.99
kinase perturbation	0.93
PubMedID	0.85
transcription factor binding site profile	0.81
microRNA	0.76

Protein Classes

PANTHER Classes

Protein / Structural Protein / Testin

Protein / Cytoskeletal Protein / Actin Family Cytoskeletal Protein / Testin

DTO Classes

Protein / Cellular Structure / Actin Family Cytoskeletal Protein / Testin

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 165.85   (req: < 5)

Gene RIFs: 33   (req: <= 3)

Antibodies: 176   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 165.85   (req: >= 5)

Gene RIFs: 33   (req: > 3)

Antibodies: 176   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0