Tchem EPHA6 Ephrin type-A receptor 6

Protein Summary

Description

Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity).

Uniprot Accession IDs

• Q9UF33
• D6RAL5

Gene Name

• EPHA6

Ensembl ID

• ENST00000502694
• ENSP00000423950
• ENSG00000080224
• ENST00000514100
• ENSP00000421711

Symbol

• EHK2
• HEK12
• EHK2
• EK12
• EPA6
• EHK-2
• HEK12
• PRO57066

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
molecular function	0.98
gene perturbation	0.78
trait	0.75
cell type or tissue	0.74

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Tk Group / Eph Family / Ephrin Type-a Receptor 6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.47   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 338   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.47   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 338   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0