Tchem MALT1 Mucosa-associated lymphoid tissue lymphoma translocation protein 1

Protein Summary

Description

Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. Involved in the induction of T helper 17 cells (Th17) differentiation. Cleaves RC3H1 and ZC3H12A in response to T-cell receptor (TCR) stimulation which releases their cooperatively repressed targets to promote Th17 cell differentiation (By similarity). This gene encodes a caspase-like protease that plays a role in BCL10-induced activation of NF-kappaB. The protein is a component of the CARMA1-BCL10-MALT1 (CBM) signalosome that triggers NF-kappaB signaling and lymphoctye activation following antigen-receptor stimulation. Mutations in this gene result in immunodeficiency 12 (IMD12). This gene has been found to be recurrently rearranged in chromosomal translocations with other genes in mucosa-associated lymphoid tissue lymphomas, including a t(11;18)(q21;q21) translocation with the baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) locus [BIRC3(API2)-MALT1], and a t(14;18)(q32;q21) translocation with the immunoglobulin heavy chain locus (IGH-MALT1). Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2018]

Uniprot Accession IDs

• Q9UDY8
• Q9NTB7
• Q9ULX4

Gene Name

• MALT1

Ensembl ID

• ENST00000345724
• ENSP00000304161
• ENSG00000172175
• ENST00000348428
• ENSP00000319279
• ENST00000649217
• ENSP00000497997

Symbol

• MLT
• MLT
• MLT1
• IMD12
• PCASP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.99
protein domain	0.97
kinase perturbation	0.81
histone modification site profile	0.8
transcription factor	0.8

Protein Classes

PANTHER Classes

Protein / ... / Cysteine Protease / Mucosa-associated Lymphoid Tissue Lymphoma Translocation Protein 1

DTO Classes

Protein / Enzyme / Protease / Cysteine Protease / Mucosa-associated Lymphoid Tissue Lymphoma Translocation Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 363.63   (req: < 5)

Gene RIFs: 157   (req: <= 3)

Antibodies: 670   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 363.63   (req: >= 5)

Gene RIFs: 157   (req: > 3)

Antibodies: 670   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 115

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1