Property Summary

NCBI Gene PubMed Count 19
PubMed Score 21.10
PubTator Score 15.64

Knowledge Summary


No data available


  Disease Sources (2)

Disease Target Count P-value
psoriasis 6685 5.14369994153751E-47
lung adenocarcinoma 2714 2.21369297030354E-14
malignant mesothelioma 3163 7.65809646586366E-10
colon cancer 1475 1.21491485971849E-6
posterior fossa group B ependymoma 1530 1.02243128266873E-4
ductal carcinoma in situ 1745 2.095237775046E-4
dermatomyositis 967 9.4866418752623E-4
invasive ductal carcinoma 2950 0.00123908252452767
breast carcinoma 1614 0.00204713850916701
osteosarcoma 7933 0.00533831557693293
fibroadenoma 557 0.0144334547157559


  Differential Expression (11)

Disease log2 FC p
malignant mesothelioma -4.900 0.000
osteosarcoma 1.957 0.005
colon cancer -1.800 0.000
breast carcinoma -2.200 0.002
fibroadenoma -3.200 0.014
posterior fossa group B ependymoma 1.200 0.000
lung adenocarcinoma -1.200 0.000
ductal carcinoma in situ -4.000 0.000
invasive ductal carcinoma -4.200 0.001
dermatomyositis -1.800 0.001
psoriasis -1.600 0.000


Accession Q9UBY9 B3KQ37 C9K0Y0 Q9NU17 HspB7
Symbols cvHSP


PANTHER Protein Class (1)

  Ortholog (9)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Chicken OMA EggNOG Inparanoid
Anole lizard OMA EggNOG Inparanoid

Gene RIF (12)

25889438 HSPB7 loci is associated in the pathophysiologuy of ischemic heart failure.
24585183 Results imply that HSBP7 is likely to be a tumor suppressor gene regulated by p53 and its downregulation by hypermethylation may play a critical role in renal carcinogenesis.
22785082 HSPB7 is a potential early biomarker after MI and serves as an independent risk factor of ACS in patients with acute chest pain.
21731611 Overexpression of HSPB1, as well as HSPB6, HSPB7 and HSPB8 independently protect against tachycardia remodeling by attenuation of the RhoA GTPase pathway at different levels.
20975947 Data show a significant association between a SNP in HSPB7 gene (rs1739843, minor allele frequency 39%) and idiopathic DCM.
20975947 Observational study of gene-disease association. (HuGE Navigator)
20877624 Observational study of gene-disease association. (HuGE Navigator)
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20124441 The rs1738943 shows that although this SNP is located within HSPB7, it resides in a block of high LD that spans HSPB7 and a nearby gene, CLCNKA, which encodes a voltage-sensitive chloride channel expressed mainly in the kidney.
20038796 Cardiac signaling genes exhibit unexpected sequence diversity in sporadic cardiomyopathy, revealing HSPB7 polymorphisms associated with disease.

AA Sequence

LREDGSLTIRARRHPHTEHVQQTFRTEIKI                                            141 - 170

Text Mined References (20)

PMID Year Title
25889438 2015 Involvement of BAG3 and HSPB7 loci in various etiologies of systolic heart failure: Results of a European collaboration assembling more than 2000 patients.
25416956 2014 A proteome-scale map of the human interactome network.
24585183 2014 Downregulation of the tumor suppressor HSPB7, involved in the p53 pathway, in renal cell carcinoma by hypermethylation.
22785082 2012 Association of plasma concentration of small heat shock protein B7 with acute coronary syndrome.
21731611 2011 HSPB1, HSPB6, HSPB7 and HSPB8 protect against RhoA GTPase-induced remodeling in tachypaced atrial myocytes.
20975947 2010 Genetic association study identifies HSPB7 as a risk gene for idiopathic dilated cardiomyopathy.
20877624 2010 Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
20628086 2010 Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
20124441 2010 Common variants in HSPB7 and FRMD4B associated with advanced heart failure.
20038796 2010 Cardiac signaling genes exhibit unexpected sequence diversity in sporadic cardiomyopathy, revealing HSPB7 polymorphisms associated with disease.