Property Summary

NCBI Gene PubMed Count 71
Grant Count 43
R01 Count 35
Funding $3,180,809.77
PubMed Score 249.79
PubTator Score 142.11

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (7)

Disease log2 FC p
Rheumatoid Arthritis 1.100 0.033
osteosarcoma 1.601 0.015
primitive neuroectodermal tumor 1.100 0.000
juvenile dermatomyositis 1.159 0.000
Pick disease 1.100 0.008
ovarian cancer -2.200 0.000
cystic fibrosis and chronic rhinosinusit... 1.187 0.001

MLP Assay (3)

AID Type Active / Inconclusive / Inactive Description
588579 confirmatory 2159 / 5211 / 396841 qHTS for Inhibitors of Polymerase Kappa
588638 summary 0 / 0 / 0 qHTS for Inhibitors of Polymerase Kappa: Summary
720501 confirmatory 696 / 223 / 0 qHTS for Inhibitors of Polymerase Kappa: Confirmatory Assay for Cherry-picked Compounds

Gene RIF (57)

PMID Text
26765445 POLK protein polymorphisms may influence the risk of developing breast cancer among Chinese women.
26046662 Somatic Mutations in Catalytic Core of POLK Reported in Prostate Cancer Alter Translesion DNA Synthesis
26031400 POLK not only protects cells from genotoxic DNA lesions via DNA polymerase activities, but also contributes to genome integrity by acting as a non-catalytic protein against oxidative damage caused by hydrogen peroxide and menadione.
25899385 The structural dynamics of DinB1 changes upon substrate binding, noncognate DNA damage prevents the formation of the active conformation of DINB1.
25684709 The steric gate is crucial for rNTP discrimination because of its role in specifically promoting a dNTP-induced conformational change and that rNTP discrimination occurs in a relatively closed state of the polymerases.
25294835 The study shows that the Werner syndrome protein stimulates the 8-oxo-dG bypass activity of hpol kappa in vitro by enhancing the correct base insertion opposite the lesion, as well as extension from dC:8-oxo-dG base pairs.
25148552 role of the unique Polkappa gap and N-clasp structural features in the fidelity of minor groove lesion processing with extensive molecular modeling and molecular dynamics simulations to pinpoint their functioning in lesion bypass
25080294 The molecular mechanism of 3-nitrobenzanthrone genotoxicity in HEK293 cells is reported.
25065501 A slow conformational change after the nucleotidyl transfer is the rate-limiting step for hpol kappa catalysis.
24948471 polymorphism of POLK, an important gene in TLS, participates in platinum-chemotherapy tolerance and side-effect
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AA Sequence

MDSTKEKCDSYKDDLLLRMGLNDNKAGMEGLDKEKINKIIMEATKGSRFYGNELKKEKQVNQRIENMMQQ      1 - 70
KAQITSQQLRKAQLQVDRFAMELEQSRNLSNTIVHIDMDAFYAAVEMRDNPELKDKPIAVGSMSMLSTSN     71 - 140
YHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEVKEILADYDPNFMAMSLDEAYLNITKHLEE    141 - 210
RQNWPEDKRRYFIKMGSSVENDNPGKEVNKLSEHERSISPLLFEESPSDVQPPGDPFQVNFEEQNNPQIL    211 - 280
QNSVVFGTSAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPNRQAVMDFIKDLP    281 - 350
IRKVSGIGKVTEKMLKALGIITCTELYQQRALLSLLFSETSWHYFLHISLGLGSTHLTRDGERKSMSVER    351 - 420
TFSEINKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKE    421 - 490
LLKTEIDADFPHPLRLRLMGVRISSFPNEEDRKHQQRSIIGFLQAGNQALSATECTLEKTDKDKFVKPLE    491 - 560
MSHKKSFFDKKRSERKWSHQDTFKCEAVNKQSFQTSQPFQVLKKKMNENLEISENSDDCQILTCPVCFRA    561 - 630
QGCISLEALNKHVDECLDGPSISENFKMFSCSHVSATKVNKKENVPASSLCEKQDYEAHPKIKEISSVDC    631 - 700
IALVDTIDNSSKAESIDALSNKHSKEECSSLPSKSFNIEHCHQNSSSTVSLENEDVGSFRQEYRQPYLCE    701 - 770
VKTGQALVCPVCNVEQKTSDLTLFNVHVDVCLNKSFIQELRKDKFNPVNQPKESSRSTGSSSGVQKAVTR    771 - 840
TKRPGLMTKYSTSKKIKPNNPKHTLDIFFK                                            841 - 870
//

Text Mined References (72)

PMID Year Title
26765445 2016 Association Between Single Nucleotide Polymorphisms in DNA Polymerase Kappa Gene and Breast Cancer Risk in Chinese Han Population: A STROBE-Compliant Observational Study.
26046662 2015 Somatic Mutations in Catalytic Core of POLK Reported in Prostate Cancer Alter Translesion DNA Synthesis.
26031400 2015 Catalytic and non-catalytic roles of DNA polymerase ? in the protection of human cells against genotoxic stresses.
25899385 2015 Noncognate DNA damage prevents the formation of the active conformation of the Y-family DNA polymerases DinB and DNA polymerase ?.
25684709 2015 Steric gate residues of Y-family DNA polymerases DinB and pol kappa are crucial for dNTP-induced conformational change.
25294835 2014 The Werner syndrome protein limits the error-prone 8-oxo-dG lesion bypass activity of human DNA polymerase kappa.
25148552 2014 Structural and dynamic characterization of polymerase ?'s minor groove lesion processing reveals how adduct topology impacts fidelity.
25080294 2014 Mutational analysis of the C8-guanine adduct of the environmental carcinogen 3-nitrobenzanthrone in human cells: critical roles of DNA polymerases ? and ? and Rev1 in error-prone translesion synthesis.
25065501 2014 Elucidation of kinetic mechanisms of human translesion DNA polymerase ? using tryptophan mutants.
24948471 2014 Association of POLK polymorphisms with platinum-based chemotherapy response and severe toxicity in non-small cell lung cancer patients.
More...