Tbio POLK DNA polymerase kappa

Protein Summary

Description

DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity. This gene encodes a member of the DNA polymerase type-Y family of proteins. The encoded protein is a specialized DNA polymerase that catalyzes translesion DNA synthesis, which allows DNA replication in the presence of DNA lesions. Human cell lines lacking a functional copy of this gene exhibit impaired genome integrity and enhanced susceptibility to oxidative damage. Mutations in this gene that impair enzyme activity may be associated with prostate cancer in human patients. [provided by RefSeq, Sep 2016]

Uniprot Accession IDs

• Q9UBT6
• B2RBD2
• Q5Q9G5
• Q5Q9G6
• Q5Q9G7
• Q5Q9G8
• Q86VJ8
• Q8IZY0
• Q8IZY1
• Q8NB30
• Q96L01
• Q96Q86
• Q96Q87
• Q9UHC5

Gene Name

• POLK

Ensembl ID

• ENST00000241436
• ENSP00000241436
• ENSG00000122008
• ENST00000504026
• ENSP00000425075
• ENST00000508526
• ENSP00000426853
• ENST00000509126
• ENSP00000423532
• ENST00000510815
• ENSP00000422094
• ENST00000515295
• ENSP00000424174

Symbol

• DINB1
• DINP
• POLQ
• DINB1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.85
histone modification site profile	0.74
biological term	0.66
tissue sample	0.61
cell type or tissue	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.77   (req: < 5)

Gene RIFs: 77   (req: <= 3)

Antibodies: 296   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.77   (req: >= 5)

Gene RIFs: 77   (req: > 3)

Antibodies: 296   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0