GULP1
PTB domain-containing engulfment adapter protein 1
Protein Summary
May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6. The protein encoded by this gene is an adapter protein necessary for the engulfment of apoptotic cells by phagocytes. Several transcript variants, some protein coding and some thought not to be protein coding, have been found for this gene. [provided by RefSeq, Nov 2011]
- ENST00000359135
- ENSP00000352047
- ENSG00000144366
- ENST00000409580
- ENSP00000386289
- ENST00000409609
- ENSP00000386867
- ENST00000409637
- ENSP00000386402
- ENST00000409805
- ENSP00000387171
- ENST00000409830
- ENSP00000386732
- ENST00000409843
- ENSP00000387144
- ENST00000410051
- ENSP00000387013
- CED6
- GULP
- CED6
- GULP
- CED-6
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.91 | ||
PubMedID | 0.9 | ||
interacting protein | 0.86 | ||
virus perturbation | 0.76 | ||
small molecule perturbation | 0.75 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 101.54 (req: < 5)
Gene RIFs: 18 (req: <= 3)
Antibodies: 178 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 101.54 (req: >= 5)
Gene RIFs: 18 (req: > 3)
Antibodies: 178 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0