Tbio TNFRSF10D Tumor necrosis factor receptor superfamily member 10D

Protein Summary

Description

Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplamic death domain. This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9UBN6
• B2R8W0
• Q9Y6Q4

Gene Name

• TNFRSF10D

Ensembl ID

• ENST00000312584
• ENSP00000310263
• ENSG00000173530

Symbol

• DCR2
• TRAILR4
• TRUNDD
• DCR2
• CD264
• TRUNDD
• TRAILR4
• TRAIL-R4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.74
PubMedID	0.71
phenotype	0.57
biological term	0.53
microRNA	0.51

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.58   (req: < 5)

Gene RIFs: 41   (req: <= 3)

Antibodies: 695   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.58   (req: >= 5)

Gene RIFs: 41   (req: > 3)

Antibodies: 695   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0