Tchem TRPC4 Short transient receptor potential channel 4

Protein Summary

Description

Form a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Mediates cation entry, with an enhanced permeability to barium over calcium. May also be activated by intracellular calcium store depletion. This gene encodes a member of the canonical subfamily of transient receptor potential cation channels. The encoded protein forms a non-selective calcium-permeable cation channel that is activated by Gq-coupled receptors and tyrosine kinases, and plays a role in multiple processes including endothelial permeability, vasodilation, neurotransmitter release and cell proliferation. Single nucleotide polymorphisms in this gene may be associated with generalized epilepsy with photosensitivity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]

Uniprot Accession IDs

• Q9UBN4
• B1ALE0
• B1ALE1
• B1ALE2
• Q15721
• Q3SWS6
• Q96P03
• Q96P04
• Q96P05
• Q9UIB0
• Q9UIB1
• Q9UIB2
• TrpC4

Gene Name

• TRPC4

Ensembl ID

• ENST00000338947
• ENSP00000342580
• ENSG00000133107
• ENST00000355779
• ENSP00000348025
• ENST00000358477
• ENSP00000351264
• ENST00000379673
• ENSP00000368995
• ENST00000379679
• ENSP00000369001
• ENST00000379705
• ENSP00000369027
• ENST00000488717
• ENSP00000435969
• ENST00000625583
• ENSP00000486109

Symbol

• TRP4
• HTRP4
• HTRP-4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.94
protein domain	0.92
trait	0.86
cellular component	0.73
histone modification site profile	0.71

Protein Classes

PANTHER Classes

Protein / Transporter / Ion Channel / Short Transient Receptor Potential Channel 4

DTO Classes

Protein / Ion Channel / Transient Receptor Potential Calcium Channel (Trp-cc) Family / Strpc Subfamily / Trpc4 Sub-subfamily / Short Transient Receptor Potential Channel 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 336.1   (req: < 5)

Gene RIFs: 48   (req: <= 3)

Antibodies: 279   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 336.1   (req: >= 5)

Gene RIFs: 48   (req: > 3)

Antibodies: 279   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1