| Tbio | Set1/Ash2 histone methyltransferase complex subunit ASH2 |
Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis.
Comments
Property Summary
| NCBI Gene PubMed Count | 46 |
| Grant Count | 32 |
| R01 Count | 20 |
| Funding | $1,845,146.16 |
| PubMed Score | 32.46 |
| PubTator Score | 46.81 |
| Disease | Z-score | Confidence |
|---|---|---|
| Kabuki syndrome 27 | 3.572 | 1.8 |
| Leukemia 88 | 3.545 | 1.8 |
| Menopause present (finding) 20 | ||
| osteosarcoma 7,933 |
| PMID | Text |
|---|---|
| 25996283 | the histone methyltransferase core enzyme ASH2L was bound at EGFR in the germinal matrix and in gliomas where levels of H3K4me3 are high, and the histone acetyltransferase P300 was bound in samples with H3K27ac enrichment |
| 25258321 | ASH2L enhances ERalpha expression as a coactivator of GATA3 in breast cancers |
| 25023704 | Ash2L acts in concert with P53 promoter occupancy to activate RNA Polymerase II by aiding formation of a stable transcription pre-initiation complex required for its activation. |
| 24680668 | Non active site mutations in the MLL1 SET domain render the protein defective for H3K4 dimethylation by the MLL1 core complex, which is associated with a loss of the ability of MLL1 to interact with WRAD or with the RbBP5/Ash2L heterodimer. |
| 24235145 | Data indicate that MLL1 methylates Ash2L in the absence of histone H3, but only when assembled within a complex with WDR5 and RbBP5. |
| 23453805 | H2B dependent regulation of MLL family histone methylatransferases depends on the N-terminal WH motif of ASH2L. |
| 22231628 | crystal structure of the C-terminal SPRY domain of human Ash2L |
| 21660059 | The structure shows that Ash2L contains an atypical PHD finger that does not have histone tail-binding activity. |
| 21642971 | ASH2L binds DNA using a forkhead-like helix-wing-helix (HWH) domain. |
| 21445285 | NF-Y acts upstream of H3K4me3 deposition by recruiting Ash2L |
| More... |
MAAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDV 1 - 70 SGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFM 71 - 140 TNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTT 141 - 210 RQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTS 211 - 280 GNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDP 281 - 350 HAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGA 351 - 420 WYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYI 421 - 490 NLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLKQTPHSEIIFYKNGVNQGVAYKDIFEG 491 - 560 VYFPAISLYKSCTVSINFGPCFKYPPKDLTYRPMSDMGWGAVVEHTLADVLYHVETEVDGRRSPPWEP 561 - 628 //
| PMID | Year | Title |
|---|---|---|
| 25996283 | 2015 | EGFR promoter exhibits dynamic histone modifications and binding of ASH2L and P300 in human germinal matrix and gliomas. |
| 25416956 | 2014 | A proteome-scale map of the human interactome network. |
| 25258321 | 2014 | Absent, small or homeotic 2-like protein (ASH2L) enhances the transcription of the estrogen receptor ? gene through GATA-binding protein 3 (GATA3). |
| 25023704 | 2015 | Ash2L enables P53-dependent apoptosis by favoring stable transcription pre-initiation complex formation on its pro-apoptotic target promoters. |
| 24680668 | 2014 | A non-active-site SET domain surface crucial for the interaction of MLL1 and the RbBP5/Ash2L heterodimer within MLL family core complexes. |
| 24235145 | 2014 | Automethylation activities within the mixed lineage leukemia-1 (MLL1) core complex reveal evidence supporting a "two-active site" model for multiple histone H3 lysine 4 methylation. |
| 23870121 | 2013 | SET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53. |
| 23453805 | 2013 | ASH2L regulates ubiquitylation signaling to MLL: trans-regulation of H3 K4 methylation in higher eukaryotes. |
| 23414517 | 2013 | A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome. |
| 23307926 | 2013 | A genome-wide association study of early menopause and the combined impact of identified variants. |
| More... |
