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  5. Set1/Ash2 histone methyltransferase complex subunit ASH2

Tbio Set1/Ash2 histone methyltransferase complex subunit ASH2

Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis.

 Comments

Property Summary

NCBI Gene PubMed Count 56
PubMed Score 33.66
PubTator Score 46.81

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (3)

Disease Target Count P-value
osteosarcoma 7950 2.5e-04
Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 0.8
Disease Target Count Z-score Confidence
Kabuki syndrome 27 4.018 2.0
Leukemia 104 3.646 1.8

Expression

  Differential Expression (1)

Disease log2 FC p
osteosarcoma -1.582 2.5e-04

Synonym

Accession Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62
Symbols ASH2
Bre2
ASH2L1
ASH2L2

Gene

ASH2L

PANTHER Protein Class (2)

PDB

5F6K   3RSN   3S32   3TOJ   4RIQ   4X8N   4X8P   5F6L  

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

 UniProt Keyword (16)

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 GO Function (6)

 GO Component (7)

 GO Process (11)

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 Compartment GO Term (29)

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 IMPC Phenotype (5)

 MGI Phenotype (2)

 GWAS Trait (1)

 HCA RNA Cell Line (56)

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Pathway (16)

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Gene RIF (22)

AA Sequence 

MAAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDV      1 - 70
SGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFM     71 - 140
TNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTT    141 - 210
RQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTS    211 - 280
GNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDP    281 - 350
HAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGA    351 - 420
WYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYI    421 - 490
NLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLKQTPHSEIIFYKNGVNQGVAYKDIFEG    491 - 560
VYFPAISLYKSCTVSINFGPCFKYPPKDLTYRPMSDMGWGAVVEHTLADVLYHVETEVDGRRSPPWEP      561 - 628
//

Text Mined References (63)

PMID Year Title