You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
PI4KB
Phosphatidylinositol 4-kinase beta

Protein Summary
Description
Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368872
  • ENSP00000357866
  • ENSG00000143393
  • ENST00000368873
  • ENSP00000357867
  • ENST00000368874
  • ENSP00000357868
  • ENST00000529142
  • ENSP00000433149

Symbol
  • PIK4CB
  • NPIK
  • PI4K92
  • PIK4CB
  • PI4KBETA
  • PI4K-BETA
  • PI4KIIIBETA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
protein domain
0.85
transcription factor perturbation
0.84
disease perturbation
0.83
ligand (protein) perturbation
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.95   (req: < 5)
Gene RIFs: 43   (req: <= 3)
Antibodies: 124   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.95   (req: >= 5)
Gene RIFs: 43   (req: > 3)
Antibodies: 124   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 44
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0