Tbio RNF7 RING-box protein 2

Protein Summary

Description

Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription (PubMed:10851089). CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets (By similarity). Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 via its interaction with UBE2F. May play a role in protecting cells from apoptosis induced by redox agents. The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9UBF6
• A8K1H9
• A8MTB5
• C9JYL3
• D3DNF7
• D3DNF8
• Q9BXN8
• Q9Y5M7
• Rbx2

Gene Name

• RNF7

Ensembl ID

• ENST00000273480
• ENSP00000273480
• ENSG00000114125
• ENST00000393000
• ENSP00000376725
• ENST00000477012
• ENSP00000419339
• ENST00000480908
• ENSP00000419084

Symbol

• RBX2
• ROC2
• SAG
• SAG
• ROC2
• rbx2
• CKBBP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.95
virus perturbation	0.83
transcription factor binding site profile	0.77
disease perturbation	0.68
protein complex	0.66

Protein Classes

PANTHER Classes

Protein / Ligase / Ubiquitin-protein Ligase / Ring-box Protein 2

DTO Classes

Protein / Enzyme / Ligase / Ubiquitin-protein Ligase / Ring-box Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.53   (req: < 5)

Gene RIFs: 24   (req: <= 3)

Antibodies: 173   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.53   (req: >= 5)

Gene RIFs: 24   (req: > 3)

Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0