Property Summary
| NCBI Gene PubMed Count | 35 |
| Grant Count | 25 |
| R01 Count | 4 |
| Funding | $4,424,976.25 |
| PubMed Score | 50.12 |
| PubTator Score | 27.47 |
| Disease | log2 FC | p |
|---|---|---|
| esophageal adenocarcinoma | -4.400 | 0.024 |
| psoriasis | 7.000 | 0.000 |
| cutaneous lupus erythematosus | 3.500 | 0.003 |
| non-small cell lung cancer | 4.362 | 0.000 |
| intraductal papillary-mucinous neoplasm ... | 2.100 | 0.008 |
| colon cancer | 1.400 | 0.003 |
| pancreatic cancer | 2.300 | 0.004 |
| lung cancer | -4.900 | 0.018 |
| cystic fibrosis | 4.700 | 0.000 |
| nasopharyngeal carcinoma | -3.400 | 0.000 |
| PMID | Text |
|---|---|
| 23820115 | Results implicate that SPRR3 might serve as a radiation-sensitive predictor of ESCC. |
| 22076481 | This study demonstrates that SPRR3 promotes BC cell proliferation by enhancing p53 degradation via the AKT and MAPK pathways |
| 21777580 | The quantitative analysis of SPRR3 mRNA is a robust and reliable method to monitor the malignant transformation of the healthy esophageal mucosa into esophageal squamous cell carcinoma. |
| 21490620 | The SPRR3 variant associated with eczema carried an extra 24-bp repeat in the central domain, which may alter the physical properties of the cornified cell envelope |
| 20599699 | two isoforms of SPRR3 were characterized from saliva of preterm human newborn and autoptic fetal oral mucosa, parotid and submandibular gland samples. |
| 20379613 | Results suggest that increased expression of SPRR3 is involved in colorectal tumorigenesis. |
| 19211270 | Sciellin, SPRR3, and periplakin transcripts were all upregulated (4.67-, 4.95-, 2.77-fold, respectively) by prolonged exposure to cyclic strain (24-72 h), but not at earlier time points. |
| 18832573 | These data suggest that SPRR3 may play a role in vascular smooth muscle cells adaptation to local biomechanical stress within the plaque microenvironment. |
| 18643845 | Association of psoriasis to PGLYRP and SPRR genes at PSORS4 locus on 1q shows heterogeneity between Finnish, Swedish and Irish families. |
| 17935133 | Esophagin/SPRR3 may play a role in the maintenance of normal esophageal epithelial homeostasis, and aberrant expression of Esophagin/SPRR3 may contribute to the tumorigenesis of esophageal squamous cell carcinoma |
| More... |
| PMID | Year | Title |
|---|---|---|
| 23820115 | 2013 | Small proline-rich repeat protein 3 enhances the sensitivity of esophageal cancer cells in response to DNA damage-induced apoptosis. |
| 23376485 | 2013 | Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. |
| 22076481 | 2012 | Expression of SPRR3 is associated with tumor cell proliferation in less advanced stages of breast cancer. |
| 21777580 | 2011 | Quantitative evaluation of SPRR3 expression in esophageal squamous cell carcinoma by qPCR and its potential use as a biomarker. |
| 21490620 | 2011 | Association screening in the Epidermal Differentiation Complex (EDC) identifies an SPRR3 repeat number variant as a risk factor for eczema. |
| 20599699 | 2010 | Characterization of two isoforms of human SPRR3 from saliva of preterm human newborn and autoptic fetal oral mucosa, parotid and submandibular gland samples. |
| 20379613 | Upregulation of SPRR3 promotes colorectal tumorigenesis. | |
| 19211270 | Biomechanical stress induces novel arterial intima-enriched genes: implications for vascular adaptation to stress. | |
| 19199708 | 2009 | Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). |
| 19056867 | 2009 | Large-scale proteomics and phosphoproteomics of urinary exosomes. |
| More... |
