Tbio NCDN Neurochondrin

Protein Summary

Description

Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling (By similarity). Required for the spatial learning process. Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth. This gene encodes a leucine-rich cytoplasmic protein, which is highly similar to a mouse protein that negatively regulates Ca/calmodulin-dependent protein kinase II phosphorylation and may be essential for spatial learning processes. Several alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9UBB6
• D3DPR9
• Q9UBY2
• Q9Y4A6
• Q9Y4D9

Gene Name

• NCDN

Ensembl ID

• ENST00000356090
• ENSP00000348394
• ENSG00000020129
• ENST00000373243
• ENSP00000362340
• ENST00000373253
• ENSP00000362350

Symbol

• KIAA0607

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.72
transcription factor binding site profile	0.72
transcription factor	0.69
cell line	0.68
virus perturbation	0.64

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.67   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 194   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.67   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 194   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0