Tbio SLC17A6 Vesicular glutamate transporter 2

Protein Summary

Description

Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.

Uniprot Accession IDs

• Q9P2U8
• A6NKS2
• VGluT2

Gene Name

• SLC17A6

Ensembl ID

• ENST00000263160
• ENSP00000263160
• ENSG00000091664

Symbol

• DNPI
• VGLUT2
• DNPI
• VGLUT2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.71
gene perturbation	0.63
molecular function	0.63
cell line	0.59
disease	0.57

Protein Classes

PANTHER Classes

Protein / Transporter / Cation Transporter / Vesicular Glutamate Transporter 2

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc17 Phosphate And Organic Anion Transporter Family / Vesicular Glutamate Transporters (Vgluts) / Vesicular Glutamate Transporter 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 838.48   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 212   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 838.48   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 212   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0