Tbio SLC17A7 Vesicular glutamate transporter 1

Protein Summary

Description

Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. The protein encoded by this gene is a vesicle-bound, sodium-dependent phosphate transporter that is specifically expressed in the neuron-rich regions of the brain. It is preferentially associated with the membranes of synaptic vesicles and functions in glutamate transport. The protein shares 82% identity with the differentiation-associated Na-dependent inorganic phosphate cotransporter and they appear to form a distinct class within the Na+/Pi cotransporter family. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9P2U7
• B4DFR9
• B4DG46
• Q6PCD0
• VGluT1

Gene Name

• SLC17A7

Ensembl ID

• ENST00000221485
• ENSP00000221485
• ENSG00000104888
• ENST00000600601
• ENSP00000470338

Symbol

• BNPI
• VGLUT1
• BNPI
• VGLUT1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.95
cellular component	0.75
gene perturbation	0.66
small molecule perturbation	0.61
biological process	0.6

Protein Classes

PANTHER Classes

Protein / Transporter / Cation Transporter / Vesicular Glutamate Transporter 1

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc17 Phosphate And Organic Anion Transporter Family / Vesicular Glutamate Transporters (Vgluts) / Vesicular Glutamate Transporter 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 732.04   (req: < 5)

Gene RIFs: 18   (req: <= 3)

Antibodies: 220   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 732.04   (req: >= 5)

Gene RIFs: 18   (req: > 3)

Antibodies: 220   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0