Property Summary

NCBI Gene PubMed Count 9
PubMed Score 1.41
PubTator Score 1.34

Knowledge Summary


No data available


  Disease Sources (1)

Disease Target Count P-value
malignant mesothelioma 3163 2.07561434075858E-9
psoriasis 6685 8.15023221762116E-5
ovarian cancer 8492 8.66825688290027E-5
posterior fossa group B ependymoma 1530 1.92018751723361E-4
intraductal papillary-mucinous adenoma (IPMA) 2956 2.22353044612281E-4
lung cancer 4473 9.25942786478656E-4
adrenocortical carcinoma 1427 0.00299829688420144
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.00439716719723054
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.00459250218839497
invasive ductal carcinoma 2950 0.00653203481732449
colon cancer 1475 0.0114408409887372
subependymal giant cell astrocytoma 2287 0.0240362971353067
mucosa-associated lymphoid tissue lymphoma 480 0.0267194491386982



Accession Q9P299
Symbols zeta2-COP


  Ortholog (11)

Species Source
Chimp OMA Inparanoid
Macaque OMA Inparanoid
Mouse OMA Inparanoid
Rat OMA Inparanoid
Dog OMA Inparanoid
Horse OMA Inparanoid
Cow OMA Inparanoid
Opossum OMA Inparanoid
Anole lizard OMA Inparanoid
C. elegans OMA Inparanoid
S.cerevisiae OMA Inparanoid

Gene RIF (2)

21746916 The knockdown of COPZ1, but not of COPZ2 encoding isoform coatomer protein complex zeta2, caused Golgi apparatus collapse, blocked autophagy, and induced apoptosis in both proliferating and nondividing tumor cells.
19167404 The solution structure of a truncated form (residues 1-149; zeta-COP149) of human zeta-COP (total 177 residues), is reported.

AA Sequence


Text Mined References (9)

PMID Year Title
22949513 2012 Genome-wide association analysis of genetic generalized epilepsies implicates susceptibility loci at 1q43, 2p16.1, 2q22.3 and 17q21.32.
21746916 2011 Tumor-specific silencing of COPZ2 gene encoding coatomer protein complex subunit ? 2 renders tumor cells dependent on its paralogous gene COPZ1.
19167404 2009 Solution structure of human zeta-COP: direct evidences for structural similarity between COP I and clathrin-adaptor coats.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14729954 2004 Novel isotypic gamma/zeta subunits reveal three coatomer complexes in mammals.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11056392 2000 Identification and characterization of novel isoforms of COP I subunits.
10982407 2000 RGS4 and RGS2 bind coatomer and inhibit COPI association with Golgi membranes and intracellular transport.
8940050 1996 In vivo assembly of coatomer, the COP-I coat precursor.