| Tbio | Zinc finger protein ZFAT |
May be involved in transcriptional regulation. Overexpression causes down-regulation of a number of genes involved in the immune response. Some genes are also up-regulated (By similarity).
This gene encodes a protein that likely binds DNA and functions as a transcriptional regulator involved in apoptosis and cell survival. This gene resides in a susceptibility locus for autoimmune thyroid disease (AITD) on chromosome 8q24. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2009]
This gene encodes a protein that likely binds DNA and functions as a transcriptional regulator involved in apoptosis and cell survival. This gene resides in a susceptibility locus for autoimmune thyroid disease (AITD) on chromosome 8q24. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2009]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Cardiovascular system disease | 194 | 0.0 | 2.0 |
| Disease | Target Count |
|---|---|
| Autoimmune Thyroid Disease, Susceptibility To, 3 | 2 |
| Species | Source |
|---|---|
| Chimp | OMA EggNOG |
| Macaque | OMA EggNOG Inparanoid |
| Mouse | OMA EggNOG Inparanoid |
| Rat | OMA EggNOG Inparanoid |
| Dog | OMA EggNOG Inparanoid |
| Cow | OMA EggNOG Inparanoid |
| Opossum | OMA EggNOG Inparanoid |
| Platypus | OMA EggNOG |
| Anole lizard | OMA EggNOG Inparanoid |
| Xenopus | OMA EggNOG Inparanoid |
| PMID | Text |
|---|---|
| 25801860 | We describe the structural features of the ZFAT ZFs, including the structural differences on the putative DNA recognition surfaces among the ZFAT ZFs, and the unique interaction mode within the tandem ZFs of ZF4 and ZF5 |
| 22894909 | ZFAT is paternally expressed in the placenta (as ZFAT-AS1, a non-coding antisense RNA)but biallelic in other tissues. |
| 22706687 | ZFAT polymorphism was associated with the Hashimoto disease severity but not with its development. |
| 20645017 | These results suggest that ZFAT may have critical roles in the capillary-like network formation that is involved in vascular remodeling. |
| 20549515 | Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) |
| 20453441 | It plays a specific role in differentiation and immunologic stimulation in B and T cells to cause autoimmune thyroid disease and contains AT-hook domain and 18 C2H2-type zin finger domain. |
| 20379614 | Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 19847924 | Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) |
| 19162026 | ZFAT protein is a critical regulator involved in apoptosis and cell survival for immune-related cells |
| 15294872 | Polymorphism, Single Nucleotide in ZFAT is associated with autoimmune thyroid disease |
METRAAENTAIFMCKCCNLFSPNQSELLSHVSEKHMEEGVNVDEIIIPLRPLSTPEPPNSSKTGDEFLVM 1 - 70 KRKRGRPKGSTKKSSTEEELAENIVSPTEDSPLAPEEGNSLPPSSLECSKCCRKFSNTRQLRKHICIIVL 71 - 140 NLGEEEGEAGNESDLELEKKCKEDDREKASKRPRSQKTEKVQKISGKEARQLSGAKKPIISVVLTAHEAI 141 - 210 PGATKIVPVEAGPPETGATNSETTSADLVPRRGYQEYAIQQTPYEQPMKSSRLGPTQLKIFTCEYCNKVF 211 - 280 KFKHSLQAHLRIHTNEKPYKCPQCSYASAIKANLNVHLRKHTGEKFACDYCSFTCLSKGHLKVHIERVHK 281 - 350 KIKQHCRFCKKKYSDVKNLIKHIRDAHDPQDKKVKEALDELCLMTREGKRQLLYDCHICERKFKNELDRD 351 - 420 RHMLVHGDKWPFACELCGHGATKYQALELHVRKHPFVYVCAVCRKKFVSSIRLRTHIKEVHGAAQEALVF 421 - 490 TSSINQSFCLLEPGGDIQQEALGDQLQLVEEEFALQGVNALKEEACPGDTQLEEGRKEPEAPGEMPAPAV 491 - 560 HLASPQAESTALPPCELETTVVSSSDLHSQEVVSDDFLLKNDTSSAEAHAAPEKPPDMQHRSSVQTQGEV 561 - 630 ITLLLSKAQSAGSDQESHGAQSPLGEGQNMAVLSAGDPDPSRCLRSNPAEASDLLPPVAGGGDTITHQPD 631 - 700 SCKAAPEHRSGITAFMKVLNSLQKKQMNTSLCERIRKVYGDLECEYCGKLFWYQVHFDMHVRTHTREHLY 701 - 770 YCSQCHYSSITKNCLKRHVIQKHSNILLKCPTDGCDYSTPDKYKLQAHLKVHTALDKRSYSCPVCEKSFS 771 - 840 EDRLIKSHIKTNHPEVSMSTISEVLGRRVQLKGLIGKRAMKCPYCDFYFMKNGSDLQRHIWAHEGVKPFK 841 - 910 CSLCEYATRSKSNLKAHMNRHSTEKTHLCDMCGKKFKSKGTLKSHKLLHTADGKQFKCTVCDYTAAQKPQ 911 - 980 LLRHMEQHVSFKPFRCAHCHYSCNISGSLKRHYNRKHPNEEYANVGTGELAAEVLIQQGGLKCPVCSFVY 981 - 1050 GTKWEFNRHLKNKHGLKVVEIDGDPKWETATEAPEEPSTQYLHITEAEEDVQGTQAAVAALQDLRYTSES 1051 - 1120 GDRLDPTAVNILQQIIELGAETHDATALASVVAMAPGTVTVVKQVTEEEPSSNHTVMIQETVQQASVELA 1121 - 1190 EQHHLVVSSDDVEGIETVTVYTQGGEASEFIVYVQEAMQPVEEQAVEQPAQEL 1191 - 1243 //
| PMID | Year | Title |
|---|---|---|
| 25801860 | 2015 | Solution structures of the DNA-binding domains of immune-related zinc-finger protein ZFAT. |
| 25429064 | 2015 | Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. |
| 25201988 | 2014 | Common genetic variants associated with cognitive performance identified using the proxy-phenotype method. |
| 24665060 | 2014 | Genome-wide association study of smoking behaviours among Bangladeshi adults. |
| 22894909 | 2012 | A genome-wide approach reveals novel imprinted genes expressed in the human placenta. |
| 22706687 | 2012 | Associations between autoimmune thyroid disease prognosis and functional polymorphisms of susceptibility genes, CTLA4, PTPN22, CD40, FCRL3, and ZFAT, previously revealed in genome-wide association studies. |
| 22589738 | 2012 | Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. |
| 21998595 | 2011 | Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry. |
| 21626137 | 2011 | Two-marker association tests yield new disease associations for coronary artery disease and hypertension. |
| 20881960 | 2010 | Hundreds of variants clustered in genomic loci and biological pathways affect human height. |
| More... |
