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Tbio Zinc finger protein ZFAT

May be involved in transcriptional regulation. Overexpression causes down-regulation of a number of genes involved in the immune response. Some genes are also up-regulated (By similarity).

This gene encodes a protein that likely binds DNA and functions as a transcriptional regulator involved in apoptosis and cell survival. This gene resides in a susceptibility locus for autoimmune thyroid disease (AITD) on chromosome 8q24. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2009]

 Comments

Property Summary

NCBI Gene PubMed Count 25
PubMed Score 30.93
PubTator Score 13.21

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (6)

Disease Target Count Z-score Confidence
Thyroiditis, Autoimmune 4 0.0 0.0
Disease Target Count
Autoimmune thyroiditis 27
Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 1.1
Endometrial cancer 311 0.0 0.5
Disease Target Count Z-score Confidence
Acquired metabolic disease 336 0.0 1.0
Cardiovascular system disease 246 0.0 3.0
Disease Target Count Z-score Confidence
Croup 12 3.61 1.8
Urethral obstruction 5 3.003 1.5

Expression

Synonym

Accession Q9P243 B7ZL15 E9PER3 Q3MIM5 Q6PJ01 Q75PJ6 Q75PJ7 Q75PJ9 Q86X64
Symbols AITD3
ZFAT1
ZNF406

Gene

ZFAT

PDB

2ELM   2ELN   2ELO   2ELP   2ELQ   2ELR   2ELS   2ELT   2ELU   2ELV   2RSH   2RSI   2RSJ   2RUT   2RUU   2RUV   2RUW   2RUX   2RUY   2RUZ   2RV0   2RV1   2RV2   2RV3   2RV6   2RV7  

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

 UniProt Keyword (14)

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 GO Function (3)

 GO Component (2)

 GO Process (2)

 Compartment GO Term (16)

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 MGI Phenotype (5)

 GWAS Trait (12)

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 HCA RNA Cell Line (56)

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Gene RIF (11)

AA Sequence 

METRAAENTAIFMCKCCNLFSPNQSELLSHVSEKHMEEGVNVDEIIIPLRPLSTPEPPNSSKTGDEFLVM      1 - 70
KRKRGRPKGSTKKSSTEEELAENIVSPTEDSPLAPEEGNSLPPSSLECSKCCRKFSNTRQLRKHICIIVL     71 - 140
NLGEEEGEAGNESDLELEKKCKEDDREKASKRPRSQKTEKVQKISGKEARQLSGAKKPIISVVLTAHEAI    141 - 210
PGATKIVPVEAGPPETGATNSETTSADLVPRRGYQEYAIQQTPYEQPMKSSRLGPTQLKIFTCEYCNKVF    211 - 280
KFKHSLQAHLRIHTNEKPYKCPQCSYASAIKANLNVHLRKHTGEKFACDYCSFTCLSKGHLKVHIERVHK    281 - 350
KIKQHCRFCKKKYSDVKNLIKHIRDAHDPQDKKVKEALDELCLMTREGKRQLLYDCHICERKFKNELDRD    351 - 420
RHMLVHGDKWPFACELCGHGATKYQALELHVRKHPFVYVCAVCRKKFVSSIRLRTHIKEVHGAAQEALVF    421 - 490
TSSINQSFCLLEPGGDIQQEALGDQLQLVEEEFALQGVNALKEEACPGDTQLEEGRKEPEAPGEMPAPAV    491 - 560
HLASPQAESTALPPCELETTVVSSSDLHSQEVVSDDFLLKNDTSSAEAHAAPEKPPDMQHRSSVQTQGEV    561 - 630
ITLLLSKAQSAGSDQESHGAQSPLGEGQNMAVLSAGDPDPSRCLRSNPAEASDLLPPVAGGGDTITHQPD    631 - 700
SCKAAPEHRSGITAFMKVLNSLQKKQMNTSLCERIRKVYGDLECEYCGKLFWYQVHFDMHVRTHTREHLY    701 - 770
YCSQCHYSSITKNCLKRHVIQKHSNILLKCPTDGCDYSTPDKYKLQAHLKVHTALDKRSYSCPVCEKSFS    771 - 840
EDRLIKSHIKTNHPEVSMSTISEVLGRRVQLKGLIGKRAMKCPYCDFYFMKNGSDLQRHIWAHEGVKPFK    841 - 910
CSLCEYATRSKSNLKAHMNRHSTEKTHLCDMCGKKFKSKGTLKSHKLLHTADGKQFKCTVCDYTAAQKPQ    911 - 980
LLRHMEQHVSFKPFRCAHCHYSCNISGSLKRHYNRKHPNEEYANVGTGELAAEVLIQQGGLKCPVCSFVY    981 - 1050
GTKWEFNRHLKNKHGLKVVEIDGDPKWETATEAPEEPSTQYLHITEAEEDVQGTQAAVAALQDLRYTSES   1051 - 1120
GDRLDPTAVNILQQIIELGAETHDATALASVVAMAPGTVTVVKQVTEEEPSSNHTVMIQETVQQASVELA   1121 - 1190
EQHHLVVSSDDVEGIETVTVYTQGGEASEFIVYVQEAMQPVEEQAVEQPAQEL                    1191 - 1243
//

Text Mined References (26)

PMID Year Title