Property Summary

NCBI Gene PubMed Count 18
PubMed Score 601.89
PubTator Score 68.37

Knowledge Summary


No data available


  Disease Sources (3)

Disease Target Count P-value
posterior fossa group B ependymoma 1530 2.87578675226829E-9
ovarian cancer 8492 1.00041357817957E-7
malignant mesothelioma 3163 7.50871346992642E-6
pituitary cancer 1972 1.12722583213321E-5
sonic hedgehog group medulloblastoma 1482 5.49979174599134E-5
Breast cancer 3099 5.42351424591099E-4
glioblastoma 5572 0.0010802194306345
pediatric high grade glioma 2712 0.0012789708817133
hereditary spastic paraplegia 313 0.00144422208353815
pancreatic cancer 2300 0.00381196600389333
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.00385033080502308
primary pancreatic ductal adenocarcinoma 1271 0.00513109512997236
ductal carcinoma in situ 1745 0.00513527889670199
lung cancer 4473 0.00564011916091174
aldosterone-producing adenoma 664 0.00798025929107852
active ulcerative colitis 477 0.0128540587481436
invasive ductal carcinoma 2950 0.0130750166666665
chronic lymphocytic leukemia 244 0.014502565009745
sarcoidosis 368 0.0153816601271459
Multiple myeloma 1328 0.0236568844144986
primary Sjogren syndrome 789 0.0238279802509821
astrocytoma 1493 0.0253633456420662
spina bifida 1064 0.0488254391825407
Disease Target Count Z-score Confidence
Obesity 616 0.0 1.0
Disease Target Count Z-score Confidence
Follicular mucinosis 5 3.871 1.9
Cancer 2346 3.262 1.6



Accession Q9P1T7 Q9P1T6
Symbols HIC


PANTHER Protein Class (1)

  Ortholog (9)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG
Mouse OMA EggNOG Inparanoid
Rat OMA Inparanoid
Dog OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Anole lizard EggNOG Inparanoid
Xenopus EggNOG Inparanoid

Gene RIF (12)

26469549 HIC specifically interacts with HTLV-1 Tax and negatively regulates Tax transactivational activity by altering its subcellular distribution and stability.
21401918 We demonstrate that HIC selectively interferes with Rev NLS interaction with importin beta and impedes its nuclear import and function, but does not affect Rev nuclear import mediated by transportin.
21401918 Downregulation of HIV-1 Rev activity by HIC is dependent on the I-mfa domain in a cell-specific manner
20417616 These data reveal for the first time that I-mfa domain proteins interact with LANA and negatively regulate LANA-mediated activation of Wnt signaling-dependent transcription by inhibiting the formation of the LANA.GSK-3beta complex.
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
19582149 strict regulation of HIC expression at the levels of mRNA stability, translation efficiency and protein stability suggests that expression of the HIC protein and its involvement in the various pathways is required only under specific cellular conditions
19428567 This study describes that the immune expression of HIC is cell-specific, dynamic, and identifies the HIC gene as an IL-2 responsive gene.
17289077 Downregulation of HIV-1 Rev activity by HIC is dependent on the I-mfa domain in a cell-specific manner
16260749 Downregulation of HIV-1 Rev activity by HIC is dependent on the I-mfa domain in a cell-specific manner
12944466 Downregulation of HIV-1 Rev activity by HIC is dependent on the I-mfa domain in a cell-specific manner

AA Sequence

DCNCPCDMDCGIMDACCESSDCLEICMECCGICFPS                                      211 - 246

Text Mined References (20)

PMID Year Title
26469549 2015 I-mfa domain proteins specifically interact with HTLV-1 Tax and repress its transactivating functions.
23818313 2013 Combined linkage and association analyses identify a novel locus for obesity near PROX1 in Asians.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
21401918 2011 Intermolecular masking of the HIV-1 Rev NLS by the cellular protein HIC: novel insights into the regulation of Rev nuclear import.
20417616 2010 Human I-mfa domain proteins specifically interact with KSHV LANA and affect its regulation of Wnt signaling-dependent transcription.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
19582149 2009 The complex regulation of HIC (Human I-mfa domain containing protein) expression.
19428567 2009 Expression profile and differential regulation of the Human I-mfa domain-Containing protein (HIC) gene in immune cells.
19041912 2009 The 3'UTR of HIC mRNA improves the production of recombinant proteins in Chinese hamster ovary cells.
18669648 2008 A quantitative atlas of mitotic phosphorylation.