Property Summary

NCBI Gene PubMed Count 8
Grant Count 5
R01 Count 4
Funding $218,169.01
PubMed Score 15.82
PubTator Score 12.29

Knowledge Summary

Patent (1,721)

TINX Plot

  Disease Relevance (1)

Disease Z-score Confidence
Idiopathic generalized epilepsy 15 3.142 1.6

Gene RIF (2)

PMID Text
23315425 biogenic amines potently regulate blood cell functions via TAAR1 and TAAR2 and open the perspective of their specific pharmacological modulation.
16878137 Previous studies reported TAAR expression in brain. This paper found TAAR expression only in olfactory epithelial cells and that each TAAR detects a unique set of amine ligands. TAARs seem to function as a family of chemosensory receptors for amines.

AA Sequence

MAVSSEQHELSHFKRTQTKKEKFNCSEYGNRSCPENERSLGVRVAMYSFMAGSIFITIFGNLAMIISISY      1 - 70
FKQLHTPTNFLILSMAITDFLLGFTIMPYSMIRSVENCWYFGLTFCKIYYSFDLMLSITSIFHLCSVAID     71 - 140
RFYAICYPLLYSTKITIPVIKRLLLLCWSVPGAFAFGVVFSEAYADGIEGYDILVACSSSCPVMFNKLWG    141 - 210
TTLFMAGFFTPGSMMVGIYGKIFAVSRKHAHAINNLRENQNNQVKKDKKAAKTLGIVIGVFLLCWFPCFF    211 - 280
TILLDPFLNFSTPVVLFDALTWFGYFNSTCNPLIYGFFYPWFRRALKYILLGKIFSSCFHNTILCMQKES    281 - 350
E//

Text Mined References (8)

PMID Year Title
23315425 2013 Biogenic amines activate blood leukocytes via trace amine-associated receptors TAAR1 and TAAR2.
18240029 2008 Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors.
16878137 2006 A second class of chemosensory receptors in the olfactory epithelium.
15718104 2005 Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14574404 2003 The DNA sequence and analysis of human chromosome 6.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
10684976 2000 Cloning and characterization of additional members of the G protein-coupled receptor family.