Property Summary

NCBI Gene PubMed Count 14
PubMed Score 6.61
PubTator Score 5.82

Knowledge Summary


No data available


  Disease Sources (3)

Disease Target Count
Myeloproliferative disease 7
Disease Target Count P-value
nasopharyngeal carcinoma 1056 7.23936184488471E-8
atypical teratoid / rhabdoid tumor 4369 2.53036848919517E-4
adult high grade glioma 2148 4.69293432725078E-4
ovarian cancer 8492 5.06227385314102E-4
glioblastoma 5572 0.00104814291752013
primary pancreatic ductal adenocarcinoma 1271 0.00288374246440205
medulloblastoma, large-cell 6234 0.00304050587432492
medulloblastoma 1524 0.00379846125205788
astrocytic glioma 2241 0.00420961046119636
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.0051563944273929
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.00571928504550529
pancreatic cancer 2300 0.00972884212163705
ependymoma 2514 0.0117215507363549
oligodendroglioma 2849 0.013345592849656
Breast cancer 3099 0.0272509794404806



Accession Q9P0R6 B3KSZ0 Q9BST1 Q9NWK0 GSKIP
Symbols HSPC210




  Ortholog (12)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Horse OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Platypus OMA EggNOG
Chicken OMA EggNOG Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG Inparanoid
Zebrafish OMA EggNOG Inparanoid

Gene RIF (3)

26280900 demonstrate that overexpression of ATG2B and GSKIP enhances hematopoietic progenitor differentiation, including of megakaryocytes, by increasing progenitor sensitivity to thrombopoietin
21328310 analysis of the GSK3beta-GSKIPtide complex structure and the X-ray crystal structures of GSK3beta-FRATide and GSK3beta-AxinGID complexes suggests that the hydroxyl group of Y288 is crucial to maintaining a hydrogen bond network in GSK3beta-FRATide
16981698 GSKIP is a naturally occurring protein that is homologous with the GSK3beta interaction domain of Axin and is able to negatively regulate GSK3beta of the Wnt signaling pathway.

AA Sequence


Text Mined References (14)

PMID Year Title
26280900 2015 Germline duplication of ATG2B and GSKIP predisposes to familial myeloid malignancies.
23602568 2013 The protein interaction landscape of the human CMGC kinase group.
23455922 2013 Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.
21328310 2011 Prediction of the binding mode between GSK3? and a peptide derived from GSKIP using molecular dynamics simulation.
20043192 2010 Involvement of the residues of GSKIP, AxinGID, and FRATtide in their binding with GSK3beta to unravel a novel C-terminal scaffold-binding region.
20007971 2010 Glycogen synthase kinase 3beta interaction protein functions as an A-kinase anchoring protein.
19830702 2009 GSKIP, an inhibitor of GSK3beta, mediates the N-cadherin/beta-catenin pool in the differentiation of SH-SY5Y cells.
17353931 2007 Large-scale mapping of human protein-protein interactions by mass spectrometry.
16981698 2006 GSKIP is homologous to the Axin GSK3beta interaction domain and functions as a negative regulator of GSK3beta.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).