Property Summary

NCBI Gene PubMed Count 25
Grant Count 13
R01 Count 7
Funding $926,889.06
PubMed Score 33.00
PubTator Score 30.37

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (25)

Disease log2 FC p
urothelial carcinoma -1.600 0.004
malignant mesothelioma 1.500 0.000
cutaneous lupus erythematosus -1.400 0.005
psoriasis -1.900 0.000
glioblastoma -3.100 0.000
osteosarcoma 1.701 0.000
ependymoma -3.200 0.000
medulloblastoma -2.100 0.000
atypical teratoid / rhabdoid tumor -4.700 0.000
medulloblastoma, large-cell -3.200 0.000
primitive neuroectodermal tumor -1.900 0.001
Atopic dermatitis -1.400 0.000
adrenocortical carcinoma -1.283 0.011
lung cancer 1.800 0.012
colon cancer -2.300 0.000
active ulcerative colitis -1.154 0.016
interstitial cystitis -2.700 0.000
pediatric high grade glioma -2.500 0.000
pilocytic astrocytoma -1.400 0.000
subependymal giant cell astrocytoma -3.817 0.018
nasopharyngeal carcinoma 1.600 0.000
lung carcinoma 1.300 0.000
Pick disease -1.600 0.005
acute myeloid leukemia -1.100 0.020
pituitary cancer 1.900 0.000

Gene RIF (14)

PMID Text
24227725 Disruption of LGI1-ADAM22 interaction reduces synaptic AMPA receptors in hippocampal neurons.
23810013 Data suggest that ADAM22 plays roles in cell differentiation, cell migration, and resistance to endocrine therapy in breast cancer; ADAM22 may serve as biomarker for poor disease-free survival in breast cancer patients. [REVIEW]
22072566 findings suggest that SRC-1 switches steroid-responsive tumors to a steroid-resistant state in which the SRC-1 target gene ADAM22 has a critical role
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
20220021 Transgenic leucine-rich glioma-inactivated 4 (Lgi4) and transgenic Adam22 proteins are both expressed in Schwann cells as well as in sensory neurons; binding of Lgi4 to axonal Adam22 is required on axons to drive myelin formation.
20156119 Mutations in disintegrin domain sequence in ADAM22 gene is associted with reduced LGI4-binding abilities resulting in epilepsy.
19054571 Observational study of gene-disease association. (HuGE Navigator)
18593599 The pro domains of ADAMs are expressed as two subdomains. The most N-terminal subdomain (ADAM22-P(N)) was found to be susceptible to proteolysis and was required for folding stability of the second subdomain (ADAM22-P(C)).
18440780 our results suggest that neither ADAM22 nor any of the three Kv1 channel genes are major causative genes for ADLTE.
17884303 Differential coding potential of ADAM22 mRNAs.
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AA Sequence

MQAAVAVSVPFLLLCVLGTCPPARCGQAGDASLMELEKRKENRFVERQSIVPLRLIYRSGGEDESRHDAL      1 - 70
DTRVRGDLGGPQLTHVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGGEHCYYQGH     71 - 140
IRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEFSLDDLPSEFQQVNIT    141 - 210
PSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQ    211 - 280
LKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICS    281 - 350
LLKGGGVNEFGKTDLMAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIE    351 - 420
EYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCTLTQDSQCSDGLC    421 - 490
CKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRDRQCKYIWGQ    491 - 560
KVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLCGYLLCTNIGNIPRLGELDGEITSTLVVQQG    561 - 630
RTLNCSGGHVKLEEDVDLGYVEDGTPCGPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKC    631 - 700
VCNRHWIGSDCNTYFPHNDDAKTGITLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQRQLP    701 - 770
QGDYVKKPGDGDSFYSDIPPGVSTNSASSSKKRSNGLSHSWSERIPDTKHISDICENGRPRSNSWQGNLG    771 - 840
GNKKKIRGKRFRPRSNSTETLSPAKSPSSSTGSIASSRKYPYPMPPLPDEDKKVNRQSARLWETSI        841 - 906
//

Text Mined References (27)

PMID Year Title
24227725 2013 Autoantibodies to epilepsy-related LGI1 in limbic encephalitis neutralize LGI1-ADAM22 interaction and reduce synaptic AMPA receptors.
23810013 2013 ADAM22 as a prognostic and therapeutic drug target in the treatment of endocrine-resistant breast cancer.
22072566 2012 Global characterization of the SRC-1 transcriptome identifies ADAM22 as an ER-independent mediator of endocrine-resistant breast cancer.
21406692 2011 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
21221126 2012 Genome-wide association study of serious blistering skin rash caused by drugs.
20463223 2010 LGI1 is a Nogo receptor 1 ligand that antagonizes myelin-based growth inhibition.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
20220021 2010 Adam22 is a major neuronal receptor for Lgi4-mediated Schwann cell signaling.
20156119 2010 Biological characterization of ADAM22 variants reveals the importance of a disintegrin domain sequence in cell surface expression.
19692335 2009 Structural characterization of the ectodomain of a disintegrin and metalloproteinase-22 (ADAM22), a neural adhesion receptor instead of metalloproteinase: insights on ADAM function.
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