| Tbio | JNK1/MAPK8-associated membrane protein |
May be a regulator of the duration of MAPK8 activity in response to various stress stimuli. Facilitates degradation of misfolded endoplasmic reticulum (ER) luminal proteins through the recruitment of components of the proteasome and endoplasmic reticulum-associated degradation (ERAD) system (By similarity).
Comments
| Disease | Target Count | P-value |
|---|---|---|
| ovarian cancer | 8520 | 1.4e-06 |
| tuberculosis and treatment for 6 months | 409 | 7.3e-05 |
| Pick disease | 1894 | 5.2e-04 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 2.0e-02 |
| medulloblastoma, large-cell | 6241 | 2.4e-02 |
| pancreatic ductal adenocarcinoma liver metastasis | 1962 | 3.7e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Large cell medulloblastoma | 5 | 4.688 | 2.3 |
| Disease | log2 FC | p |
|---|---|---|
| intraductal papillary-mucinous neoplasm ... | 1.500 | 2.0e-02 |
| medulloblastoma, large-cell | -1.200 | 2.4e-02 |
| ovarian cancer | -2.200 | 1.4e-06 |
| pancreatic ductal adenocarcinoma liver m... | -1.598 | 3.7e-02 |
| Pick disease | -1.100 | 5.2e-04 |
| tuberculosis and treatment for 6 months | 1.200 | 7.3e-05 |
| Species | Source | Disease |
|---|---|---|
| Inparanoid EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG |
MFGAAARSADLALLEKNLQAAHGCLGLYCGKTLLFKNGSTEIYGECGVCPRGQRTNAQKYCQPCTESPEL 1 - 70 YDWLYLGFMAMLPLVLHWFFIEWYSGKKSSSALFQHITALFECSMAAIITLLVSDPVGVLYIRSCRVLML 71 - 140 SDWYTMLYNPSPDYVTTVHCTHEAVYPLYTIVFIYYAFCLVLMMLLRPLLVKKIACGLGKSDRFKSIYAA 141 - 210 LYFFPILTVLQAVGGGLLYYAFPYIILVLSLVTLAVYMSASEIENCYDLLVRKKRLIVLFSHWLLHAYGI 211 - 280 ISISRVDKLEQDLPLLALVPTPALFYLFTAKFTEPSRILSEGANGH 281 - 326 //
