Tbio CRIPT Cysteine-rich PDZ-binding protein

Protein Summary

Description

Involved in the cytoskeletal anchoring of DLG4 in excitatory synapses. This gene encodes a protein that binds to the PDZ3 peptide recognition domain. The encoded protein may modulates protein interactions with the cytoskeleton. A mutation in this gene resulted in short stature with microcephaly and distinctive facies. [provided by RefSeq, Jun 2014]

Uniprot Accession IDs

• Q9P021

Gene Name

• CRIPT

Ensembl ID

• ENST00000238892
• ENSP00000238892
• ENSG00000119878

Symbol

• SSMDF
• HSPC139

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.91
transcription factor perturbation	0.74
transcription factor binding site profile	0.69
kinase perturbation	0.66
microRNA	0.65

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.94   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 89   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.94   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 89   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0