| Tbio | 39S ribosomal protein L15, mitochondrial |
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the EcoL15 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 15q. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung cancer | 2890 | 7.4e-16 |
| ovarian cancer | 8520 | 1.4e-04 |
| lung cancer | 4740 | 7.6e-04 |
| Pick disease | 1894 | 3.0e-03 |
| Multiple myeloma | 1332 | 3.3e-03 |
| acute myeloid leukemia | 783 | 5.7e-03 |
| Breast cancer | 3578 | 2.2e-02 |
| astrocytic glioma | 2597 | 2.2e-02 |
| colon cancer | 1478 | 4.4e-02 |
| Disease | log2 FC | p |
|---|---|---|
| acute myeloid leukemia | -1.600 | 5.7e-03 |
| astrocytic glioma | -1.200 | 2.2e-02 |
| Breast cancer | 4.200 | 2.2e-02 |
| colon cancer | -1.300 | 4.4e-02 |
| lung cancer | 1.600 | 7.6e-04 |
| Multiple myeloma | 1.406 | 3.3e-03 |
| non-small cell lung cancer | 1.040 | 7.4e-16 |
| ovarian cancer | 2.200 | 1.4e-04 |
| Pick disease | -1.100 | 3.0e-03 |
MAGPLQGGGARALDLLRGLPRVSLANLKPNPGSKKPERRPRGRRRGRKCGRGHKGERQRGTRPRLGFEGG 1 - 70 QTPFYIRIPKYGFNEGHSFRRQYKPLSLNRLQYLIDLGRVDPSQPIDLTQLVNGRGVTIQPLKRDYGVQL 71 - 140 VEEGADTFTAKVNIEVQLASELAIAAIEKNGGVVTTAFYDPRSLDIVCKPVPFFLRGQPIPKRMLPPEEL 141 - 210 VPYYTDAKNRGYLADPAKFPEARLELARKYGYILPDITKDELFKMLCTRKDPRQIFFGLAPGWVVNMADK 211 - 280 KILKPTDENLLKYYTS 281 - 296 //
