Tbio CNIH4 Protein cornichon homolog 4

Protein Summary

Description

Involved in G protein-coupled receptors (GPCRs) trafficking from the endoplasmic reticulum to the cell surface; it promotes the exit of GPCRs from the early secretory pathway, likely through interaction with the COPII machinery (PubMed:24405750).

Uniprot Accession IDs

• Q9P003
• A8K1Q8
• B2R553
• Q9H0X8
• CNIH-4

Gene Name

• CNIH4

Ensembl ID

• ENST00000366857
• ENSP00000355822
• ENSG00000143771
• ENST00000465271
• ENSP00000420443

Symbol

• CNIH2
• CNIH-4
• HSPC163

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.99
kinase perturbation	0.81
virus perturbation	0.79
disease perturbation	0.74
transcription factor binding site profile	0.73

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Protein Cornichon Homolog 4

DTO Classes

Protein / Transporter / Protein Cornichon Homolog 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.64   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 65   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.64   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 65   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0