Property Summary

NCBI Gene PubMed Count 406
PubMed Score 2228.28
PubTator Score 912.90

Knowledge Summary


No data available


  Disease Sources (4)

Disease Target Count P-value
psoriasis 6685 2.31174946146933E-233
lung carcinoma 2844 9.78107381330736E-16
ulcerative colitis 2087 3.93934464547788E-9
non-small cell lung cancer 2798 9.6793142711562E-5
group 3 medulloblastoma 2254 1.64226469373033E-4
sarcoidosis 368 5.1418285728997E-4
Atopic dermatitis 944 5.91391704721049E-4
tuberculosis and treatment for 3 months 327 6.66369725838397E-4
active Crohn's disease 918 0.00191931679074356
uncontrolled asthma 67 0.00290980465420836
cystic fibrosis 1670 0.00333630780778269
oligodendroglioma 2849 0.00519761786300517
head and neck cancer 270 0.00527391883242087
intraductal papillary-mucinous adenoma (IPMA) 2956 0.0065978724865728
interstitial cystitis 2299 0.00795052589805019
head and neck cancer and chronic obstructive pulmonary disease 237 0.00821333245074182
nasopharyngeal carcinoma 1056 0.0130441265309292
non diabetic and post-ischemic heart failure 200 0.0370004726052261
osteosarcoma 7933 0.0412078805280201
Breast cancer 3099 0.0461995821157103



Accession Q9NZQ7 B2RBA2 B4DU27 Q14CJ2 Q2V8D5 Q66RK1 Q6WEX4 Q9NUZ5 PD-L1
Symbols B7-H



3BIK   3BIS   3FN3   3SBW   4Z18   4ZQK   5C3T   5J89   5J8O  

  Ortholog (12)

Gene RIF (395)

27065104 Inhibitory Profile of Liver CD68+ Cells during HCV Infection as Observed by an Increased CD80 and PD-L1 but Not CD86 Expression
26927720 Data suggest signaling via CD279/PDCD1 and its ligand CD274/PD-L1 is effective chemotherapy target in non-small cell lung cancer; PD-L1 is best currently available immunohistochemistry biomarker for response to immune checkpoint inhibitors. [REVIEW]
26927379 Data show that interferon-gamma could up-regulate the number of IL-10(+)T cells differentiated in the present of placenta mesenchymal stem cells (hPMSCs) by enhancing the expression of programmed death ligand 1 (PD-L1) in hPMSCs.
26913631 We observed cogain or coamplification of CD274 and PDCD1LG2 in 32 of 48 cervical and 10 of 23 vulvar squamous cell carcinomas
26867643 PD-L1 expression in neutrophils is elevated in patients with systemic lupus erythematosus.
26771872 Proposed that PD-L1 expression in combination with CD8+ tumor infiltrating lymphocyte density could be a useful predictive biomarker in patients with stage III NSCLC.
26762740 Genetic amplification of the PD-L1 gene was correlated with Non-Small Cell Lung Cancer.
26754191 PD-L1 is a novel target of HIF-2alpha and provide evidence of a link between VHL mutations, the HIF-2alpha signalling pathway and PD-L1 expression, indicating that the VHL-HIF-2alpha axis has a crucial role in the PD-L1 response in this disease
26752545 PD-L1 and PD-L2 are useful new markers for identifying select histiocyte and dendritic cell disorders and reveal novel patient populations as rational candidates for immunotherapy
26676749 overexpressed EGFR significantly correlated with JAK2 and PD-L1 expression in a large cohort of head and neck cancer specimens.

AA Sequence

KQSDTHLEET                                                                281 - 290

Text Mined References (408)

PMID Year Title
27065104 2016 A Potential Inhibitory Profile of Liver CD68+ Cells during HCV Infection as Observed by an Increased CD80 and PD-L1 but Not CD86 Expression.
26927720 2016 Non-Small Cell Lung Cancer, PD-L1, and the Pathologist.
26927379 2016 [IFN-? up-regulates PD-L1 expression in human placenta mesenchymal stem cells and enhances cell ability to induce the differentiation of IL-10+ T cells from cord blood- and peripheral blood-derived T cells].
26913631 2016 Genetic Basis for PD-L1 Expression in Squamous Cell Carcinomas of the Cervix and Vulva.
26867643 2016 PD-L1-expressing neutrophils as a novel indicator to assess disease activity and severity of systemic lupus erythematosus.
26771872 2016 Predictive relevance of PD-L1 expression combined with CD8+ TIL density in stage III non-small cell lung cancer patients receiving concurrent chemoradiotherapy.
26762740 2016 PD-L1 Is Upregulated by Simultaneous Amplification of the PD-L1 and JAK2 Genes in Non-Small Cell Lung Cancer.
26754191 2016 Kidney cancer: Programmed death ligand 1 regulation in ccRCC.
26752545 2016 Expression of Programmed Cell Death 1 Ligands (PD-L1 and PD-L2) in Histiocytic and Dendritic Cell Disorders.
26676749 2016 Identification of the Cell-Intrinsic and -Extrinsic Pathways Downstream of EGFR and IFN? That Induce PD-L1 Expression in Head and Neck Cancer.