Property Summary

NCBI Gene PubMed Count 23
PubMed Score 600.84
PubTator Score 12.96

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (1)

Disease Target Count P-value
ovarian cancer 8492 9.0387844602499E-7
dermatomyositis 967 5.71837710001679E-4
pancreatic ductal adenocarcinoma liver metastasis 1795 0.00119120943938076
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.00272494625355155
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.00529590012737287
glioblastoma 5572 0.00815974047819617
astrocytoma 1493 0.0152420431512114
non primary Sjogren syndrome sicca 840 0.0177036150523076
esophageal adenocarcinoma 737 0.0467609987466569

Expression

Synonym

Accession Q9NZN8 Q9H3E0 Q9NSX5 Q9NWR6 Q9P028
Symbols NOT2
CDC36
NOT2H
HSPC131

Gene

PANTHER Protein Class (1)

PDB

4C0D   5FU6   5FU7   4C0F  

  Ortholog (13)

Gene RIF (7)

PMID Text
24121232 The CNOT2-CNOT3 heterodimer is stabilized and tightly anchored to the surface of CNOT1 through an unexpected intertwined arrangement of peptide regions lacking defined secondary structure.
22367759 Cnot1, Cnot2, and Cnot3 represent a novel component of the core self-renewal and pluripotency circuitry conserved in mouse and human ESCs.
21299754 human CNOT2 is important for maintaining the deadenylase activity and structural integrity of the CCR4-NOT complex, thereby affecting cell viability.
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
16712523 This study shows that SMRT/NCoR-HDAC3 complex is a cofactor of CNOT2-mediated repression and suggests that transcriptional regulation by the Ccr4-Not complex involves regulation of chromatin modification.
16039607 These findings suggest that CDK11 may contribute to apoptosis by regulating the activity of NOT2 independent of its kinase activity.
14707134 major repression function of CNOT2 is localized in a specialized protein motif, the Not-Box

AA Sequence

MVRTDGHTLSEKRNYQVTNSMFGASRKKFVEGVDSDYHDENMYYSQSSMFPHRSEKDMLASPSTSGQLSQ      1 - 70
FGASLYGQQSALGLPMRGMSNNTPQLNRSLSQGTQLPSHVTPTTGVPTMSLHTPPSPSRGILPMNPRNMM     71 - 140
NHSQVGQGIGIPSRTNSMSSSGLGSPNRSSPSIICMPKQQPSRQPFTVNSMSGFGMNRNQAFGMNNSLSS    141 - 210
NIFNGTDGSENVTGLDLSDFPALADRNRREGSGNPTPLINPLAGRAPYVGMVTKPANEQSQDFSIHNEDF    211 - 280
PALPGSSYKDPTSSNDDSKSNLNTSGKTTSSTDGPKFPGDKSSTTQNNNQQKKGIQVLPDGRVTNIPQGM    281 - 350
VTDQFGMIGLLTFIRAAETDPGMVHLALGSDLTTLGLNLNSPENLYPKFASPWASSPCRPQDIDFHVPSE    351 - 420
YLTNIHIRDKLAAIKLGRYGEDLLFYLYYMNGGDVLQLLAAVELFNRDWRYHKEERVWITRAPGMEPTMK    421 - 490
TNTYERGTYYFFDCLNWRKVAKEFHLEYDKLEERPHLPSTFNYNPAQQAF                        491 - 540
//

Text Mined References (33)

PMID Year Title
26496610 2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
24121232 2013 Structure and assembly of the NOT module of the human CCR4-NOT complex.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
22959728 2013 Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1.
22367759 2012 Cnot1, Cnot2, and Cnot3 maintain mouse and human ESC identity and inhibit extraembryonic differentiation.
21981923 2011 GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets.
21406692 2011 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
21299754 2011 CNOT2 depletion disrupts and inhibits the CCR4-NOT deadenylase complex and induces apoptotic cell death.
21269460 2011 Initial characterization of the human central proteome.
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