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Tbio
GRHL1
Grainyhead-like protein 1 homolog

Protein Summary
Description
Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' (PubMed:12175488, PubMed:18288204, PubMed:29309642). Important regulator of DSG1 in the context of hair anchorage and epidermal differentiation, participates in the maintenance of the skin barrier. There is no genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity during epithelia development (By similarity). Isoform 1: Functions as transcription activator. Isoform 2: May function as a repressor in tissues where both isoform 1 and isoform 2 are expressed. This gene encodes a member of the grainyhead family of transcription factors. The encoded protein can exist as a homodimer or can form heterodimers with sister-of-mammalian grainyhead or brother-of-mammalian grainyhead. This protein functions as a transcription factor during development. [provided by RefSeq, Jun 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324907
  • ENSP00000324693
  • ENSG00000134317
  • ENST00000405379
  • ENSP00000384209
  • ENST00000472167
  • ENSP00000418275

Symbol
  • LBP32
  • MGR
  • TFCP2L2
  • MGR
  • NH32
  • LBP32
  • TFCP2L2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
molecular function
0.86
histone modification site profile
0.7
biological process
0.6
cellular component
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.55   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 116   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.55   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 116   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0