Tbio PRR13 Proline-rich protein 13

Protein Summary

Description

Negatively regulates TSP1 expression at the level of transcription. This down-regulation was shown to reduce taxane-induced apoptosis.

Uniprot Accession IDs

• Q9NZ81
• Q0V8U0
• Q6FIG7
• Q6MZP8
• Q6NXQ6
• Q6PKF9

Gene Name

• PRR13

Ensembl ID

• ENST00000379786
• ENSP00000369112
• ENSG00000205352
• ENST00000429243
• ENSP00000412064
• ENST00000549135
• ENSP00000447777
• ENST00000549581
• ENSP00000448153
• ENST00000549924
• ENSP00000448761

Symbol

• TXR1
• TXR1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.84
virus perturbation	0.76
histone modification site profile	0.73
kinase perturbation	0.71
transcription factor	0.69

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.63   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 53   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.63   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 53   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0