Tbio UBAP1 Ubiquitin-associated protein 1

Protein Summary

Description

Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2. This gene is a member of the UBA domain family, whose members include proteins having connections to ubiquitin and the ubiquitination pathway. The ubiquitin associated domain is thought to be a non-covalent ubiquitin binding domain consisting of a compact three helix bundle. This particular protein originates from a gene locus in a refined region on chromosome 9 undergoing loss of heterozygosity in nasopharyngeal carcinoma (NPC). Taking into account its cytogenetic location, this UBA domain family member is being studies as a putative target for mutation in nasopharyngeal carcinomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]

Uniprot Accession IDs

• Q9NZ09
• B7Z348
• B7Z8N9
• D3DRL7
• F5GXE2
• F5H0J8
• Q4V759
• Q53FP7
• Q5T7B3
• Q6FI75
• Q8NC52
• Q8NCG6
• Q8NCH9
• UBAP-1

Gene Name

• UBAP1

Ensembl ID

• ENST00000297661
• ENSP00000297661
• ENSG00000165006
• ENST00000359544
• ENSP00000352541
• ENST00000379186
• ENSP00000368484
• ENST00000625521
• ENSP00000486574

Symbol

• UAP
• UBAP
• NAG20
• UBAP-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.89
kinase perturbation	0.84
disease perturbation	0.74
transcription factor binding site profile	0.74
virus perturbation	0.72

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.32   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 180   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.32   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 180   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0