Tbio CALY Neuron-specific vesicular protein calcyon

Protein Summary

Description

Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis. The protein encoded by this gene is a type II single transmembrane protein. It is required for maximal stimulated calcium release after stimulation of purinergic or muscarinic but not beta-adrenergic receptors. The encoded protein interacts with D1 dopamine receptor and may interact with other DA receptor subtypes and/or GPCRs. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9NYX4
• Q5VWX3
• Q5VWY5
• Q5VWY6

Gene Name

• CALY

Ensembl ID

• ENST00000252939
• ENSP00000252939
• ENSG00000130643
• ENST00000368555
• ENSP00000357543
• ENST00000368558
• ENSP00000357546

Symbol

• DRD1IP
• NSG3
• DRD1IP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.74
histone modification site profile	0.51
gene perturbation	0.47
cell type or tissue	0.46
drug	0.46

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.98   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 86   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.98   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 86   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0