Tbio RBAK RB-associated KRAB zinc finger protein

Protein Summary

Description

May repress E2F-dependent transcription. May promote AR-dependent transcription. This gene encodes a nuclear protein which interacts with the tumor suppressor retinoblastoma 1. The two interacting proteins are thought to act as a transcriptional repressor for promoters which are activated by the E2F1 transcription factor. This protein contains a Kruppel-associated box (KRAB), which is a transcriptional repressor motif. Read-through transcripts that include exons from the downstream gene LOC389458 are expressed from this locus. [provided by RefSeq, Mar 2011]

Uniprot Accession IDs

• Q9NYW8
• A6NDF2
• A8KAK4
• B2RN44
• B9EGS1
• F8W6M7

Gene Name

• RBAK

Ensembl ID

• ENST00000353796
• ENSP00000275423
• ENSG00000146587
• ENST00000396912
• ENSP00000380120

Symbol

• ZNF769
• ZNF769

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.83
virus perturbation	0.79
microRNA	0.67
cell line	0.62
tissue sample	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.78   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 142   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.78   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0