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  6. Taste receptor type 2 member 3

Tbio Taste receptor type 2 member 3

Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.

This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. These apparently intronless taste receptor genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008]

 Comments

Property Summary

NCBI Gene PubMed Count 19
PubMed Score 3.19
PubTator Score 2.25

Knowledge Summary

Patent (1,924)

TINX Plot

  Disease Sources (1)

Disease Target Count P-value
diabetes mellitus 1663 0.00105862314600335

Expression

  Differential Expression (1)

Disease log2 FC p
diabetes mellitus 1.100 0.001

Synonym

Accession Q9NYW6 A4D1U2 Q645W2 Q75MV6 T2R3
Symbols T2R3

Gene

TAS2R3

  Ortholog (8)

Species Source
Chimp OMA EggNOG Inparanoid
Mouse OMA EggNOG
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Pig OMA EggNOG
Opossum OMA EggNOG Inparanoid
Xenopus OMA EggNOG

 Collection (1)

 GO Function (3)

 GO Component (2)

 GO Process (3)

 Compartment GO Term (9)

 HCA RNA Cell Line (37)

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Pathway (7)

 UniProt Keyword (11)

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Gene RIF (2)

PMID Text
22397221 Our results show that the expression rate of some of the T2R taste receptor genes was increased significantly in patients with phantogeusia.
19372376 Includes the study of a polymorphic upstream ORF in this gene, and shows that it functions to reduce protein levels by ~58%.

AA Sequence 

MMGLTEGVFLILSGTQFTLGILVNCFIELVNGSSWFKTKRMSLSDFIITTLALLRIILLCIILTDSFLIE      1 - 70
FSPNTHDSGIIMQIIDVSWTFTNHLSIWLATCLGVLYCLKIASFSHPTFLWLKWRVSRVMVWMLLGALLL     71 - 140
SCGSTASLINEFKLYSVFRGIEATRNVTEHFRKKRSEYYLIHVLGTLWYLPPLIVSLASYSLLIFSLGRH    141 - 210
TRQMLQNGTSSRDPTTEAHKRAIRIILSFFFLFLLYFLAFLIASFGNFLPKTKMAKMIGEVMTMFYPAGH    211 - 280
SFILILGNSKLKQTFVVMLRCESGHLKPGSKGPIFS                                      281 - 316
//

Text Mined References (19)

PMID Year Title
23568457 2013 Genetic variants associated with disordered eating.
22397221 2012 Patients with phantogeusia show increased expression of T2R taste receptor genes in their tongues.
20022913 2010 The molecular receptive ranges of human TAS2R bitter taste receptors.
19372376 2009 Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans.
15744053 2005 Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates.
15496549 2005 Evolution of bitter taste receptors in humans and apes.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
12853948 2003 The DNA sequence of human chromosome 7.
12690205 2003 Human chromosome 7: DNA sequence and biology.
12581520 2003 Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.
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