Tbio ANAPC11 Anaphase-promoting complex subunit 11

Protein Summary

Description

Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.

Uniprot Accession IDs

• Q9NYG5
• A8MTT2
• B7ZW64
• Q502X9
• Q9BW64
• Q9P0R2
• APC11

Gene Name

• ANAPC11

Ensembl ID

• ENST00000344877
• ENSP00000339695
• ENSG00000141552
• ENST00000357385
• ENSP00000349957
• ENST00000392376
• ENSP00000376181
• ENST00000571024
• ENSP00000461648
• ENST00000571570
• ENSP00000458143
• ENST00000571874
• ENSP00000459200
• ENST00000572639
• ENSP00000460678
• ENST00000572851
• ENSP00000458265
• ENST00000574924
• ENSP00000460064
• ENST00000575195
• ENSP00000458515
• ENST00000577747
• ENSP00000463567
• ENST00000578550
• ENSP00000464615
• ENST00000579978
• ENSP00000463640
• ENST00000583839
• ENSP00000463598

Symbol

• APC11
• Apc11p
• HSPC214

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.94
virus perturbation	0.92
histone modification site profile	0.8
disease perturbation	0.74
cell type or tissue	0.68

Protein Classes

PANTHER Classes

Protein / Ligase / Ubiquitin-protein Ligase / Anaphase-promoting Complex Subunit 11

DTO Classes

Protein / Enzyme / Ligase / Ubiquitin-protein Ligase / Anaphase-promoting Complex Subunit 11

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.07   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 324   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.07   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 324   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0