| Tbio | N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2 |
Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Catalyzes the initiation and elongation of poly-N-acetyllactosamine chains. Shows a marked preference for Gal(beta1-4)Glc(NAc)-based acceptors (PubMed:9892646). Probably constitutes the main polylactosamine synthase.
This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein. It prefers the substrate of lacto-N-neotetraose, and is involved in the biosynthesis of poly-N-acetyllactosamine chains. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2016]
This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein. It prefers the substrate of lacto-N-neotetraose, and is involved in the biosynthesis of poly-N-acetyllactosamine chains. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2016]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Arthritis, Rheumatoid | 174 | 0.0 | 0.0 |
| Graves Disease | 11 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| Schizophrenia | 1160 |
| Disease | Target Count | P-value |
|---|---|---|
| juvenile dermatomyositis | 1187 | 9.0e-08 |
| malignant mesothelioma | 3232 | 1.1e-06 |
| ductal carcinoma in situ | 1745 | 5.2e-04 |
| ovarian cancer | 8520 | 1.6e-03 |
| osteosarcoma | 7950 | 2.2e-03 |
| oligodendroglioma | 2850 | 2.8e-03 |
| astrocytic glioma | 2597 | 4.1e-03 |
| invasive ductal carcinoma | 2951 | 4.2e-03 |
| pancreatic carcinoma | 562 | 5.3e-03 |
| pancreatic cancer | 2398 | 5.3e-03 |
| primary Sjogren syndrome | 735 | 9.4e-03 |
| Breast cancer | 3578 | 3.7e-02 |
| group 3 medulloblastoma | 4104 | 4.3e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Rheumatoid arthritis | 1191 | 0.0 | 3.0 |
| Disease | log2 FC | p |
|---|---|---|
| astrocytic glioma | -1.300 | 4.1e-03 |
| Breast cancer | 2.900 | 3.7e-02 |
| ductal carcinoma in situ | 1.100 | 5.2e-04 |
| group 3 medulloblastoma | -1.500 | 4.3e-02 |
| invasive ductal carcinoma | 1.100 | 4.2e-03 |
| juvenile dermatomyositis | 1.098 | 9.0e-08 |
| malignant mesothelioma | -1.300 | 1.1e-06 |
| oligodendroglioma | -1.700 | 2.8e-03 |
| osteosarcoma | 1.475 | 2.2e-03 |
| ovarian cancer | 2.200 | 1.6e-03 |
| pancreatic cancer | -1.200 | 5.3e-03 |
| pancreatic carcinoma | -1.200 | 5.3e-03 |
| primary Sjogren syndrome | 1.200 | 9.4e-03 |
MSVGRRRIKLLGILMMANVFIYFIMEVSKSSSQEKNGKGEVIIPKEKFWKISTPPEAYWNREQEKLNRQY 1 - 70 NPILSMLTNQTGEAGRLSNISHLNYCEPDLRVTSVVTGFNNLPDRFKDFLLYLRCRNYSLLIDQPDKCAK 71 - 140 KPFLLLAIKSLTPHFARRQAIRESWGQESNAGNQTVVRVFLLGQTPPEDNHPDLSDMLKFESEKHQDILM 141 - 210 WNYRDTFFNLSLKEVLFLRWVSTSCPDTEFVFKGDDDVFVNTHHILNYLNSLSKTKAKDLFIGDVIHNAG 211 - 280 PHRDKKLKYYIPEVVYSGLYPPYAGGGGFLYSGHLALRLYHITDQVHLYPIDDVYTGMCLQKLGLVPEKH 281 - 350 KGFRTFDIEEKNKNNICSYVDLMLVHSRKPQEMIDIWSQLQSAHLKC 351 - 397 //
