Tchem SLC5A4 Solute carrier family 5 member 4

Protein Summary

Description

Has electrogenic activity in response to glucose, and may function as a glucose sensor (PubMed:13130073, PubMed:17110502, PubMed:20421923, PubMed:22766068). Mediates influx of sodium ions into the cell but does not transport sugars (PubMed:13130073, PubMed:22766068). Also potently activated by imino sugars such as deoxynojirimycin (DNJ) (PubMed:17110502, PubMed:20421923, PubMed:22766068).

Uniprot Accession IDs

• Q9NY91
• O15279

Gene Name

• SLC5A4

Ensembl ID

• ENST00000266086
• ENSP00000266086
• ENSG00000100191

Symbol

• SAAT1
• SGLT3
• SAAT1
• SGLT3
• DJ90G24.4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.6
cell type or tissue	0.56
pathway	0.52
cell line	0.5
metabolite	0.45

Protein Classes

PANTHER Classes

Protein / Transporter / Cation Transporter / Solute Carrier Family 5 Member 4

Protein / Transporter / Carbohydrate Transporter / Solute Carrier Family 5 Member 4

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc5 Family Of Sodium-dependent Glucose Transporters / Hexose Transporter Family / Solute Carrier Family 5 Member 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2369.26   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 99   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2369.26   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 28

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2