SLC39A1
Zinc transporter ZIP1
Protein Summary
Mediates zinc uptake. May function as a major endogenous zinc uptake transporter in many cells of the body. Responsible for the rapid uptake and accumulation of physiologically effective zinc in prostate cells. This gene encodes a member of the zinc-iron permease family. The encoded protein is localized to the cell membrane and acts as a zinc uptake transporter. This gene has been linked to prostate cancer, breast cancer, and Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
- ENST00000310483
- ENSP00000309710
- ENSG00000143570
- ENST00000356205
- ENSP00000348535
- ENST00000368621
- ENSP00000357610
- ENST00000368623
- ENSP00000357612
- ENST00000617697
- ENSP00000479421
- ENST00000621013
- ENSP00000484182
- IRT1
- ZIP1
- ZIRTL
- ZIP1
- ZIRTL
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.74 | ||
transcription factor binding site profile | 0.74 | ||
tissue sample | 0.71 | ||
histone modification site profile | 0.68 | ||
cell type or tissue | 0.67 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 178.2 (req: < 5)
Gene RIFs: 24 (req: <= 3)
Antibodies: 89 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 178.2 (req: >= 5)
Gene RIFs: 24 (req: > 3)
Antibodies: 89 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0