Property Summary

NCBI Gene PubMed Count 32
PubMed Score 71.93
PubTator Score 51.60

Knowledge Summary


No data available


  Disease Sources (4)

Disease Target Count P-value
pilocytic astrocytoma 3086 5.50347200503239E-9
ependymoma 2514 8.48484239781367E-9
pediatric high grade glioma 2712 5.47225308564683E-8
ovarian cancer 8492 3.31901981143855E-7
atypical teratoid / rhabdoid tumor 4369 1.03204692546329E-6
glioblastoma 5572 6.86171795485389E-6
Disease Target Count Z-score Confidence
Disease of mental health 22 0.0 1.0


  Differential Expression (6)

Disease log2 FC p
ependymoma 1.100 0.000
glioblastoma 1.500 0.000
atypical teratoid / rhabdoid tumor 1.400 0.000
pediatric high grade glioma 1.500 0.000
pilocytic astrocytoma 1.300 0.000
ovarian cancer 1.400 0.000


Accession Q9NY26 B4DDY7 Q5T4K1 Q8N2H7 Q9BTV0 Q9UBI7 Q9Y2Z7 Q9Y380
Symbols ZIP1


  Ortholog (9)

Species Source
Chimp OMA EggNOG
Mouse OMA EggNOG Inparanoid
Rat OMA Inparanoid
Dog OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG
C. elegans OMA EggNOG

 GWAS Trait (1)

Gene RIF (22)

26081940 Despite the fact that these preliminary findings are unlikely to be of much diagnostic significance, these findings suggest that hZip1 plays a fundamental role in the carcinogenesis of mucinous tumors.
24922175 The effect of zinc administered for 27 days on the expression of ZIP1 in peripheral white blood cells is reported.
24878177 Data suggest that high zrt- and Irt-like protein 1 (hZIP1) expression may be an indicator of good prognosis in clear cell renal cell carcinoma (ccRCC).
24488210 Data indicate that zinc transporters ZnT1 and Zip1 were the most abundantly expressed zinc transporters in leukocytes.
23921484 Data indicate that the average expression level of zinc transporter Zip2 was significantly higher and zinc transporters Zip6, Zip8 mRNA levels were significantly lower in short stature children than in health controls.
23839533 Data indicate that the expression levels of ZnT and ZIP families in the three cell lines, when treated with high concentration of ZnSO4, increased and decreased corresponding to their functions, respectively.
22349685 The results of this study showed that signi fi cant positive correlations between ZIP1,ZnT1, and ZnT6 in most brain in patient with Alzheimer's disease.
21360563 RREB-1 overexpression results in down-regulation of hZIP1 and contributes to the loss of hZIP1 expression and zinc in prostate cancer.
21103883 Differentiated Caco-2 cells tolerate significantly higher levels of zinc compared to undifferentiated Caco-2 cells, which was accompanied by upregulated ZnT-1 and downregulated ZIP1 levels.
21053094 The metallothionein gene had a higher expression in the blood, when compared to zinc transporters ZnT-1, Zip-1, and Zip-3 (p=0.01 in obese patients.

AA Sequence


Text Mined References (34)

PMID Year Title
26081940 2015 Persistent low expression of hZip1 in mucinous carcinomas of the ovary, colon, stomach and lung.
24922175 2014 Zinc fortification decreases ZIP1 gene expression of some adolescent females with appropriate plasma zinc levels.
24878177 2014 hZIP1 that is down-regulated in clear cell renal cell carcinoma is negatively associated with the malignant potential of the tumor.
24488210 2014 The alteration of zinc transporter gene expression is associated with inflammatory markers in obese women.
23921484 2013 Zip1, Zip2, and Zip8 mRNA expressions were associated with growth hormone level during the growth hormone provocation test in children with short stature.
23839533 2013 Effects of exogenous zinc on cell cycle, apoptosis and viability of MDAMB231, HepG2 and 293 T cells.
22903471 2013 Genome-wide association identifies genetic variants associated with lentiform nucleus volume in N?=?1345 young and elderly subjects.
22349685 2012 Zinc transporter mRNA levels in Alzheimer's disease postmortem brain.
21360563 2011 hZIP1 zinc transporter down-regulation in prostate cancer involves the overexpression of ras responsive element binding protein-1 (RREB-1).
21269460 2011 Initial characterization of the human central proteome.