Disease | Target Count | P-value |
---|---|---|
inflammatory breast cancer | 404 | 4.32401915043565E-5 |
colon cancer | 1475 | 1.66124570778224E-4 |
intraductal papillary-mucinous adenoma (IPMA) | 2956 | 0.00127365249970271 |
diabetes mellitus | 1663 | 0.00217554430421278 |
primary pancreatic ductal adenocarcinoma | 1271 | 0.00673292072770137 |
pancreatic cancer | 2300 | 0.00959709409431113 |
nephrosclerosis | 329 | 0.0189496373550172 |
intraductal papillary-mucinous carcinoma (IPMC) | 2988 | 0.024479460557933 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
ulcerative colitis | 2087 | 3.829 | 1.9 |
Crohn's disease | 304 | 0.0 | 2.0 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Hartnup disease | 13 | 4.128 | 2.1 |
Disease | log2 FC | p |
---|---|---|
nephrosclerosis | -1.361 | 0.019 |
primary pancreatic ductal adenocarcinoma | -1.340 | 0.007 |
intraductal papillary-mucinous adenoma (... | -2.100 | 0.001 |
intraductal papillary-mucinous carcinoma... | -1.500 | 0.024 |
colon cancer | -1.800 | 0.000 |
diabetes mellitus | 1.300 | 0.002 |
inflammatory breast cancer | -1.300 | 0.000 |
pancreatic cancer | -1.300 | 0.010 |
Species | Source |
---|---|
Chimp | OMA EggNOG |
Mouse | OMA EggNOG Inparanoid |
Rat | OMA EggNOG Inparanoid |
Dog | OMA EggNOG Inparanoid |
Cow | OMA EggNOG Inparanoid |
Opossum | OMA EggNOG Inparanoid |
PMID | Text |
---|---|
24068945 | Our results confirmed significant association to rare non-synonymous coding variants in both IL23R and CARD9, previously identified from sequencing of CD loci, as well as identified a novel association in RNF186 |
23896122 | BNip1 functions as a downstream modulator of RNF186 to direct endoplasmic reticulum stress-associated apoptotic signaling. |
23511034 | Single-nucleotide polymorphism in RNF186 gene is associated with ulcerative colitis. |
PMID | Year | Title |
---|---|---|
24068945 | 2013 | Deep resequencing of GWAS loci identifies rare variants in CARD9, IL23R and RNF186 that are associated with ulcerative colitis. |
23896122 | 2013 | A novel RING finger E3 ligase RNF186 regulate ER stress-mediated apoptosis through interaction with BNip1. |
23511034 | 2013 | Genome-wide association study of ulcerative colitis in Koreans suggests extensive overlapping of genetic susceptibility with Caucasians. |
20228799 | 2010 | Genome-wide association identifies multiple ulcerative colitis susceptibility loci. |
19122664 | 2009 | Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study. |
16710414 | 2006 | The DNA sequence and biological annotation of human chromosome 1. |
15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
14702039 | 2004 | Complete sequencing and characterization of 21,243 full-length human cDNAs. |
12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |
8125298 | 1994 | Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |